Derivatives of grindelic acid: from a non-active natural diterpene to synthetic antitumor derivatives

dc.creatorReta, Guillermo Federico
dc.creatorChiaramello, Alejandra Ilda
dc.creatorGarcía, Celina
dc.creatorLeón, Leticia G.
dc.creatorMartín, Victor S.
dc.creatorPadrón, José M.
dc.creatorTonn, Carlos Eugenio
dc.creatorDonadel, Osvaldo Juan
dc.date.accessioned2016-05-24T19:08:34Z
dc.date.accessioned2018-11-06T12:52:42Z
dc.date.available2016-05-24T19:08:34Z
dc.date.available2018-11-06T12:52:42Z
dc.date.created2016-05-24T19:08:34Z
dc.date.issued2013-06-18
dc.identifierReta, Guillermo Federico; Chiaramello, Alejandra Ilda; García, Celina; León, Leticia G.; Martín, Victor S.; et al.; Derivatives of grindelic acid: from a non-active natural diterpene to synthetic antitumor derivatives; Elsevier Masson; European Journal of Medical Chemistry; 67; 18-6-2013; 28-38
dc.identifier0223-5234
dc.identifierhttp://hdl.handle.net/11336/5823
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1870754
dc.description.abstractUsing several reactions that include homologations and asymmetric epoxidations as well as Ugi and Huisgen couplings, we generated a small focused library of new derivatives from the labdane-type diterpene grindelic acid. These compounds were evaluated as cytotoxic agents against a panel of five human solid tumor cell lines (HBL-100, HeLa, SW1573, T-47D, and WiDr). The presence of the diamide functionalizations enhanced the cytotoxic effect. N-benzyl-N-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)grindelicamide, proved to be the most active product in all cell lines tested, with values of 0.95 (± 0.38) μM against HBL-100 cells.
dc.languageeng
dc.publisherElsevier Masson
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0223523413003814
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejmech.2013.06.013
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2013.06.013
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLabdane-type diterpenes
dc.subjectMulticomponent reactions
dc.subjectDiamide derivatives
dc.subject1,2,3-Triazole
dc.titleDerivatives of grindelic acid: from a non-active natural diterpene to synthetic antitumor derivatives
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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