Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins

dc.creatorWang, HongBin
dc.creatorGutierrez Uzquiza, Alvaro
dc.creatorGarg, Rachana
dc.creatorBarrio Real, Laura
dc.creatorAbera, Mahlet B
dc.creatorLopez Haber, Cynthia
dc.creatorRosemblit, Cinthia
dc.creatorLu, Huaisheng
dc.creatorAbba, Martín Carlos
dc.creatorKazanietz, Marcelo G.
dc.date.accessioned2018-01-11T17:06:50Z
dc.date.accessioned2018-11-06T12:52:12Z
dc.date.available2018-01-11T17:06:50Z
dc.date.available2018-11-06T12:52:12Z
dc.date.created2018-01-11T17:06:50Z
dc.date.issued2014-07
dc.identifierLopez Haber, Cynthia; Garg, Rachana; Rosemblit, Cinthia; Abera, Mahlet B; Gutierrez Uzquiza, Alvaro; Kazanietz, Marcelo G.; et al.; Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins; American Society for Biochemistry and Molecular Biology; Journal Of Biological Chemistry (online); 289; 7-2014; 19823-19838
dc.identifier1083-351X
dc.identifierhttp://hdl.handle.net/11336/32973
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1870670
dc.description.abstractBackground: PKCϵ, a kinase widely implicated in tumorigenesis and metastasis, is overexpressed in many cancers. Results: Transcription factors Sp1 and STAT1 control the expression of PKCϵ in cancer cells. Conclusion: Up-regulation of PKCϵ is mediated by dysregulated transcriptional mechanisms. Significance: Our results may have significant implications for the development of approaches to target PKCϵ and its effectors in cancer therapeutics.
dc.languageeng
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1074/jbc.M114.548446
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/289/28/19823
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBREAST CANCER
dc.subjectDIACYLGLYCEROL
dc.subjectGENE EXPRESSION
dc.subjectPROTEIN KINASE C EPSILON
dc.titleTranscriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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