Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework

dc.creatorGarro, Hugo Alejandro
dc.creatorManzur, Maria Jimena
dc.creatorCiuffo, Gladys Maria
dc.creatorTonn, Carlos Eugenio
dc.creatorPungitore, Carlos Rodolfo
dc.date.accessioned2016-09-06T20:19:06Z
dc.date.accessioned2018-11-06T12:49:14Z
dc.date.available2016-09-06T20:19:06Z
dc.date.available2018-11-06T12:49:14Z
dc.date.created2016-09-06T20:19:06Z
dc.date.issued2014-01
dc.identifierGarro, Hugo Alejandro; Manzur, Maria Jimena; Ciuffo, Gladys Maria; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework; Elsevier; Bioorganic & Medicinal Chemistry Letters; 24; 3; 1-2014; 760-764
dc.identifier0960-894X
dc.identifierhttp://hdl.handle.net/11336/7494
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1870325
dc.description.abstractCoumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 lM, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 lM, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960894X13014881
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bmcl.2013.12.104
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCoumarins
dc.subjectreverse transcriptase
dc.subjectpolymerase
dc.subjectmolecular target
dc.subjectinhibition
dc.titleInhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución