Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome

dc.creatorDi Pietro, Mariana
dc.creatorScotti, Leopoldina
dc.creatorIrusta, Griselda
dc.creatorTesone, Marta
dc.creatorParborell, Maria Fernanda Agustina
dc.creatorAbramovich, Dalhia Nurit
dc.date.accessioned2017-09-12T17:23:08Z
dc.date.accessioned2018-11-06T12:34:07Z
dc.date.available2017-09-12T17:23:08Z
dc.date.available2018-11-06T12:34:07Z
dc.date.created2017-09-12T17:23:08Z
dc.date.issued2016-09-15
dc.identifierDi Pietro, Mariana; Scotti, Leopoldina; Irusta, Griselda; Tesone, Marta; Parborell, Maria Fernanda Agustina; et al.; Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome; Elsevier Ireland; Molecular and Cellular Endocrinology; 433; 15-9-2016; 47-55
dc.identifier0303-7207
dc.identifierhttp://hdl.handle.net/11336/24013
dc.identifier1872-8057
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1867905
dc.description.abstractAlterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased in follicular fluid of PCOS patients and in the ovaries of a rat model of PCOS. In the present study, we aimed to analyze the effects of local administration of PDGFB on ovarian angiogenesis, follicular development and ovulation in a DHEA-induced PCOS rat model. Ovarian PDGFB administration to PCOS rats partially restored follicular development, decreased the percentage of cysts, increased the percentage of corpora lutea, and decreased the production of anti-Müllerian hormone. In addition, PDGFB administration improved ovarian angiogenesis by reversing the increase in periendothelial cell area and restoring VEGF levels. Our results shed light into the mechanisms that lead to altered ovarian function in PCOS and provide new data for potential therapeutic strategies.
dc.languageeng
dc.publisherElsevier Ireland
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720716301873
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mce.2016.05.022
dc.relationinfo:eu-repo/semantics/altIdentifier/pmid/27256152
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectANGIOGENESIS
dc.subjectOVARY
dc.subjectPLATELET DERIVED GROWTH FACTOR
dc.subjectPOLYCYSTIC OVARY SYNDROME
dc.titleLocal administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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