dc.creator | Talevi, Alan | |
dc.date.accessioned | 2018-08-06T17:34:38Z | |
dc.date.accessioned | 2018-11-06T12:29:07Z | |
dc.date.available | 2018-08-06T17:34:38Z | |
dc.date.available | 2018-11-06T12:29:07Z | |
dc.date.created | 2018-08-06T17:34:38Z | |
dc.date.issued | 2016-03 | |
dc.identifier | Talevi, Alan; Tailored Multi-Target Agents: Applications and Design Considerations; Bentham Science Publishers; Current Pharmaceutical Design; 22; 21; 3-2016; 3164-3170 | |
dc.identifier | 1381-6128 | |
dc.identifier | http://hdl.handle.net/11336/54278 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1867162 | |
dc.description.abstract | In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in fact unintended multi-functional therapeutics that have emerged from phenotypic models. The last two decades, however, have witnessed the emergence of tailored multi-target agents, which according to our perspective combine the best aspects of target-based and phenotypic-based drug discovery. Here we discuss a number of considerations related to the design, screening and computer-aided discovery of multi-targeted drugs, along with neglected advantages that this type of agents might have in clinical trials. | |
dc.language | eng | |
dc.publisher | Bentham Science Publishers | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ingentaconnect.com/contentone/ben/cpd/2016/00000022/00000021/art00008 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | TAILORED MULTI-TARGET AGENTS | |
dc.subject | VIRTUAL SCREENING | |
dc.subject | DRUG DESIGN | |
dc.subject | IN SILICO SCREENING | |
dc.subject | BINDING EFFICIENCY METRICS | |
dc.subject | DRUG RESISTANCE | |
dc.subject | NETWORK PHARMACOLOGY | |
dc.title | Tailored Multi-Target Agents: Applications and Design Considerations | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |