dc.creator | Beckwith, Esteban Javier | |
dc.creator | Gorostiza, Ezequiel Axel | |
dc.creator | Berni, Jimena | |
dc.creator | Rezaval, Carolina | |
dc.creator | Perez Santangelo, Agustin | |
dc.creator | Nadra, Alejandro Daniel | |
dc.creator | Ceriani, Maria Fernanda | |
dc.date.accessioned | 2015-05-15T18:30:57Z | |
dc.date.available | 2015-05-15T18:30:57Z | |
dc.date.created | 2015-05-15T18:30:57Z | |
dc.date.issued | 2013-12-10 | |
dc.identifier | Beckwith, Esteban Javier; Gorostiza, Ezequiel Axel; Berni, Jimena; Rezaval, Carolina; Perez Santangelo, Agustin; et al.; Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway; Public Library of Science; PLoS Biology; 11; 12; 10-12-2013; 1-15; e1001733 | |
dc.identifier | 1544-9173 | |
dc.identifier | http://hdl.handle.net/11336/487 | |
dc.description.abstract | Living organisms use biological clocks to maintain their internal temporal order and anticipate daily environmental changes. In Drosophila, circadian regulation of locomotor behavior is controlled by ∼150 neurons; among them, neurons expressing the PIGMENT DISPERSING FACTOR (PDF) set the period of locomotor behavior under free-running conditions. To date, it remains unclear how individual circadian clusters integrate their activity to assemble a distinctive behavioral output. Here we show that the BONE MORPHOGENETIC PROTEIN (BMP) signaling pathway plays a crucial role in setting the circadian period in PDF neurons in the adult brain. Acute deregulation of BMP signaling causes period lengthening through regulation of dClock transcription, providing evidence for a novel function of this pathway in the adult brain. We propose that coherence in the circadian network arises from integration in PDF neurons of both the pace of the cell-autonomous molecular clock and information derived from circadian-relevant neurons through release of BMP ligands. | |
dc.language | eng | |
dc.publisher | Public Library of Science | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pbio.1001733 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001733 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | PIGMENT DISPERSING FACTOR | |
dc.subject | BONE MORPHOGENETIC PROTEIN | |
dc.subject | schnurri | |
dc.subject | circadian | |
dc.title | Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |