dc.creator | Gonzalez, Patricia Verónica | |
dc.creator | Machado, Ivana Noelia | |
dc.creator | Vilcaes, Aldo Alejandro | |
dc.creator | Caruso, Carla Mariana | |
dc.creator | Roth, German Alfredo | |
dc.creator | Schiöth, H. | |
dc.creator | Lasaga, Mercedes Isabel | |
dc.creator | Scimonelli, Teresa Nieves | |
dc.date.accessioned | 2017-04-10T20:47:54Z | |
dc.date.accessioned | 2018-11-06T12:25:44Z | |
dc.date.available | 2017-04-10T20:47:54Z | |
dc.date.available | 2018-11-06T12:25:44Z | |
dc.date.created | 2017-04-10T20:47:54Z | |
dc.date.issued | 2013-10 | |
dc.identifier | Gonzalez, Patricia Verónica; Machado, Ivana Noelia; Vilcaes, Aldo Alejandro; Caruso, Carla Mariana; Roth, German Alfredo; et al.; Molecular mechanisms involved in interleukin 1-beta (IL-1b)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (a-MSH); Elsevier; Brain Behavior And Immunity; 34; 10-2013; 141-150 | |
dc.identifier | 0889-1591 | |
dc.identifier | http://hdl.handle.net/11336/15109 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1866473 | |
dc.description.abstract | Pro-inflammatory cytokines can affect cognitive processes such as learning and memory. Particularly, interleukin-1β (IL-1β) influences the consolidation of hippocampus-dependent memories. We previously reported that administration of IL-1β in dorsal hippocampus impaired contextual fear memory consolidation. Different mechanisms have been implicated in the action of IL-1β on long-term potentiation (LTP), but the processes by which this inhibition occurs in vivo remain to be elucidated. We herein report that intrahippocampal injection of IL-1β induced a significant increase in p38 phosphorylation after contextual fear conditioning. Also, treatment with SB203580, an inhibitor of p38, reversed impairment induced by IL-1β on conditioned fear behavior, indicating that this MAPK would be involved in the effect of the cytokine. We also showed that IL-1β administration produced a decrease in glutamate release from dorsal hippocampus synaptosomes and that treatment with SB203580 partially reversed this effect. Our results indicated that IL-1β-induced impairment in memory consolidation could be mediated by a decrease in glutamate release. This hypothesis is sustained by the fact that treatment with d-cycloserine (DCS), a partial agonist of the NMDA receptor, reversed the effect of IL-1β on contextual fear memory. Furthermore, we demonstrated that IL-1β produced a temporal delay in ERK phosphorylation and that DCS administration reversed this effect. We also observed that intrahippocampal injection of IL-1β decreased BDNF expression after contextual fear conditioning. We previously demonstrated that α-MSH reversed the detrimental effect of IL-1β on memory consolidation. The present results demonstrate that α-MSH administration did not modify the decrease in glutamate release induced by IL-1β. However, intrahippocampal injection of α-MSH prevented the effect on ERK phosphorylation and BDNF expression induced by IL-1β after contextual fear conditioning. Therefore, in the present study we determine possible molecular mechanisms involved in the impairment induced by IL-1β on fear memory consolidation. We also established how this effect could be modulated by α-MSH. | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0889159113004182 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbi.2013.08.007 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | IL-1BETA | |
dc.subject | MEMORY CONSOLIDATION | |
dc.subject | ALPHA-MSH | |
dc.subject | GLUTAMATE RELEASE | |
dc.subject | P38 | |
dc.subject | ERK | |
dc.subject | BDNF | |
dc.title | Molecular mechanisms involved in interleukin 1-beta (IL-1b)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (a-MSH) | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |