dc.creatorDiaz, Alberto Alejandro
dc.creatorTringler, Matías
dc.creatorWray, Sandra
dc.creatorRamírez, Agustín José
dc.creatorCabrera Fischer, Edmundo Ignacio
dc.date.accessioned2018-07-06T17:13:52Z
dc.date.accessioned2018-11-06T12:24:08Z
dc.date.available2018-07-06T17:13:52Z
dc.date.available2018-11-06T12:24:08Z
dc.date.created2018-07-06T17:13:52Z
dc.date.issued2018-02
dc.identifierDiaz, Alberto Alejandro; Tringler, Matías; Wray, Sandra; Ramírez, Agustín José; Cabrera Fischer, Edmundo Ignacio; The effects of age on pulse wave velocity in untreated hypertension; Wiley Blackwell Publishing, Inc; Journal Of Clinical Hypertension; 20; 2; 2-2018; 258-265
dc.identifier1524-6175
dc.identifierhttp://hdl.handle.net/11336/51527
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1866141
dc.description.abstractIncreased arterial stiffness is an important determinant of cardiovascular risk, able to predict morbidity and mortality, and closely associated with ageing and blood pressure. The aims of this study were: (1) To determine the age-dependent reference pulse wave velocity (PWV), and compare it with values from hypertensive patients, and (2) to evaluate the impact of isolated and untreated hypertension on arterial stiffness. A total of 1079 patients were enrolled and divided into a control group (NT) of asymptomatic normotensive patients and a group of asymptomatic hypertensive patients (HT). Blood pressure, carotid-femoral PWV, and body mass index were measured in each subject, whose blood was drawn for laboratory tests. Aortic mean PWV in the NT group was 6.85 ± 1.66 m/s, which increased linearly (R2 = 0.62; P <.05) with age. In patients over 50 years of age, PWV was significantly higher than in younger patients (8.35 vs 5.92 m/s, respectively, P <.001). This significant difference persisted when observing male and female patients separately. In the hypertensive group, mean PWV value was 8.04 ± 1.8 m/s (range 4.5-15.8 m/s) and increased (R2 = 0.243; P <.05) with age. The PWV increase in HT was significantly higher (0.93 m/s per decade, P <.001) than in NT (0.44 m/s per decade). Our study provides normal values of PVW per decade, and shows that these values increase with age, especially after 50 years of age, particularly in HT patients. This stiffness growth rate may be responsible for increased cardiovascular risk in both groups.
dc.languageeng
dc.publisherWiley Blackwell Publishing, Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1111/jch.13167
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jch.13167
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectARTERIAL HYPERTENSION
dc.subjectARTERIAL STIFFNESS
dc.subjectEPIDEMIOLOGY
dc.subjectPOPULATION BASED STUDY
dc.subjectPULSE WAVE VELOCITY
dc.subjectSOUTH AMERICA
dc.titleThe effects of age on pulse wave velocity in untreated hypertension
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución