dc.creator | Sabbione, Florencia | |
dc.creator | Gabelloni, María Laura | |
dc.creator | Ernst, Glenda | |
dc.creator | Gori, María Soledad | |
dc.creator | Salamone, Gabriela Veronica | |
dc.creator | Oleastro, Matías | |
dc.creator | Trevani, Analía Silvina | |
dc.creator | Geffner, Jorge Raúl | |
dc.creator | Jancic, Carolina Cristina | |
dc.date.accessioned | 2017-11-30T20:08:58Z | |
dc.date.available | 2017-11-30T20:08:58Z | |
dc.date.created | 2017-11-30T20:08:58Z | |
dc.date.issued | 2013-12 | |
dc.identifier | Sabbione, Florencia; Gabelloni, María Laura; Ernst, Glenda; Gori, María Soledad; Salamone, Gabriela Veronica; et al.; Neutrophils suppress γδ T-cell function; Wiley VCH Verlag; European Journal of Immunology; 44; 3; 12-2013; 819-830 | |
dc.identifier | 0014-2980 | |
dc.identifier | http://hdl.handle.net/11336/29388 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.description.abstract | γδ T cells have been shown to stimulate the recruitment and activation of neutrophils through the release of a range of cytokines and chemokines. Here, we investigated the reverse relationship, showing that human neutrophils suppress the function of human blood γδ T cells. We show that the upregulation of CD25 and CD69 expression, the production of IFN-γ, and the proliferation of γδ T cells induced by (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate are inhibited by neutrophils. Spontaneous activation of γδ T cells in culture is also suppressed by neutrophils. We show that inhibitors of prostaglandin E2 and arginase I do not exert any effect, although, in contrast, catalase prevents the suppression of γδ T cells induced by neutrophils, suggesting the participation of neutrophil-derived ROS. We also show that the ROS-generating system xanthine/xanthine oxidase suppresses γδ T cells in a similar fashion to neutrophils, while neutrophils from chronic granulomatous disease patients only weakly inhibit γδ T cells. Our results reveal a bi-directional cross-talk between γδ T cells and neutrophils: while γδ T cells promote the recruitment and the activation of neutrophils to fight invading pathogens, neutrophils in turn suppress the activation of γδ T cells to contribute to the resolution of inflammation. | |
dc.language | eng | |
dc.publisher | Wiley VCH Verlag | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/eji.201343664 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/eji.201343664/abstract | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Ros | |
dc.subject | Neutrophils | |
dc.subject | Γδ T Cells | |
dc.title | Neutrophils suppress γδ T-cell function | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |