dc.creator | Bresciani, Anne Gøther | |
dc.creator | Paul, Sinu | |
dc.creator | Schommer, Nina | |
dc.creator | Dillon, Myles B. | |
dc.creator | Bancroft, Tara | |
dc.creator | Greenbaum, Jason | |
dc.creator | Sette, Alessandro | |
dc.creator | Nielsen, Morten | |
dc.creator | Peters, Bjoern | |
dc.date.accessioned | 2018-06-19T17:29:19Z | |
dc.date.accessioned | 2018-11-06T12:16:03Z | |
dc.date.available | 2018-06-19T17:29:19Z | |
dc.date.available | 2018-11-06T12:16:03Z | |
dc.date.created | 2018-06-19T17:29:19Z | |
dc.date.issued | 2016-05 | |
dc.identifier | Bresciani, Anne Gøther; Paul, Sinu; Schommer, Nina; Dillon, Myles B.; Bancroft, Tara; et al.; T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome; Wiley Blackwell Publishing, Inc; Immunology; 148; 1; 5-2016; 34-39 | |
dc.identifier | 0019-2805 | |
dc.identifier | http://hdl.handle.net/11336/49324 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1864974 | |
dc.description.abstract | Several mechanisms exist to avoid or suppress inflammatory T-cell immune responses that could prove harmful to the host due to targeting self-antigens or commensal microbes. We hypothesized that these mechanisms could become evident when comparing the immunogenicity of a peptide from a pathogen or allergen with the conservation of its sequence in the human proteome or the healthy human microbiome. Indeed, performing such comparisons on large sets of validated T-cell epitopes, we found that epitopes that are similar with self-antigens above a certain threshold showed lower immunogenicity, presumably as a result of negative selection of T cells capable of recognizing such peptides. Moreover, we also found a reduced level of immune recognition for epitopes conserved in the commensal microbiome, presumably as a result of peripheral tolerance. These findings indicate that the existence (and potentially the polarization) of T-cell responses to a given epitope is influenced and to some extent predictable based on its similarity to self-antigens and commensal antigens. | |
dc.language | eng | |
dc.publisher | Wiley Blackwell Publishing, Inc | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/imm.12585 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/imm.12585 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | BIOINFORMATICS | |
dc.subject | EPITOPES | |
dc.subject | T-CELL RECOGNITION | |
dc.title | T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |