Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases

dc.creatorTrivillin, Verónica Andrea
dc.creatorGarabalino, Marcela Alejandra
dc.creatorColombo, Lucas Luis
dc.creatorGonzález, Sara Josefina
dc.creatorFarías, Rubén Oscar
dc.creatorMonti Hughes, Andrea
dc.creatorPozzi, Emiliano César Cayetano
dc.creatorBortolussi, Silva
dc.creatorAltieri, S.
dc.creatorItoiz, María Elina
dc.creatorAromando, Romina Flavia
dc.creatorNigg, D. W.
dc.creatorSchwint, Amanda Elena
dc.date.accessioned2017-12-28T14:52:36Z
dc.date.available2017-12-28T14:52:36Z
dc.date.created2017-12-28T14:52:36Z
dc.date.issued2013-12
dc.identifierTrivillin, Verónica Andrea; Garabalino, Marcela Alejandra; Colombo, Lucas Luis; González, Sara Josefina; Farías, Rubén Oscar; et al.; Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases; Elsevier; Applied Radiation and Isotopes; 88; 12-2013; 94-98
dc.identifier0969-8043
dc.identifierhttp://hdl.handle.net/11336/31778
dc.identifierCONICET Digital
dc.identifierCONICET
dc.description.abstractBNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76 ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969804313005642
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.apradiso.2013.11.115
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBoron Biodistribution Studies
dc.subjectBpa
dc.subjectGb-10
dc.subjectBnct
dc.subjectBoron Neutron Capture Therapy
dc.subjectLung Metastases
dc.titleBiodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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