Artículos de revistas
Solvent-Free Condensation Reactions to Synthesize Five-Member Heterocycles Containing the Sulphamide Fragment.
Fecha
2016-03Registro en:
Rodriguez Arroyo, Nelson; Rozas, Maria Fernanda; Vazquez, Patricia Graciela; Romanelli, Gustavo Pablo; Mirifico, Maria Virginia; Solvent-Free Condensation Reactions to Synthesize Five-Member Heterocycles Containing the Sulphamide Fragment.; Georg Thieme Verlag Kg; Synthesis-stuttgart; 48; 3-2016; 1344-1352
0039-7881
CONICET Digital
CONICET
Autor
Rodriguez Arroyo, Nelson
Rozas, Maria Fernanda
Vazquez, Patricia Graciela
Romanelli, Gustavo Pablo
Mirifico, Maria Virginia
Resumen
We report a study of the solvent-free condensation reaction of 1,2-dicarbonyl compounds with sulfamide catalyzed by a Keggin-type acid (H3PMo12O40·nH2O, MPA) to obtain 3,4-disubstituted 1,2,5-thiadiazole 1,1-dioxide derivatives. Some reactions were also performed in solution or using nano-sized silica-supported MPA catalyst in order to compare the results under different experimental conditions. Effects of the temperature used for the thermal pretreatment of the catalyst, the reaction temperature, the molar ratios sulfamide/1,2-dicarbonyl compound and MPA/1,2-dicarbonyl compound, and alternative experimental procedures on the yield of the reaction product were investigated. Under suitable experimental conditions eight compounds were obtained in good yields. The catalyst was recycled and reused, but with some loss of its catalytic activity. The presented synthetic method is a simple, clean, and environmentally friendly alternative for synthesizing different 1,2,5-thiadiazole 1,1-dioxide derivatives.