info:eu-repo/semantics/article
Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions
Fecha
2015-04Registro en:
Sierra, Liliana Beatríz; Roco, Julieta; Alarcón, Gabriela del Jesús; Medina, Mirta; Van Nieuwenhove, Carina Paola; et al.; Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions; Elsevier; Journal of Functional Foods; 14; 4-2015; 641-649
1756-4646
2214-9414
CONICET Digital
CONICET
Autor
Sierra, Liliana Beatríz
Roco, Julieta
Alarcón, Gabriela del Jesús
Medina, Mirta
Van Nieuwenhove, Carina Paola
Peral, Maria de Los Angeles
Jerez, Susana Josefina
Resumen
The effects of dietary supplementation with Salvia hispanica (chia) oil on vascular function in hypercholesterolaemic rabbit were examined. Rabbits were fed either regular diet (CD) or 10% chia oil in regular diet or 1% cholesterol diet (HD) or diet containing 1% cholesterol and 10% chia oil (HD-Ch) during 5?6 weeks. HD increased total cholesterol, LDL and triacylglycerol levels. HD-Ch significantly attenuated the triacylglycerol rise and increased alpha linolenic acid (ALA) levels. Aorta from hypercholesterolaemic rabbits exhibited an impaired relaxation response to acetylcholine (Ach), reduced NO-release and increased intima/media ratio. Including chia oil in the HD partially normalized the response to Ach and the intima/media ratio, and totally restored the NO-release. In addition, dietary supplementation with chia oil blunted the contractile response to angiotensin II and noradrenaline. These findings suggest that increased ALA levels induced by dietary chia oil could improve vascular function under hypercholesterolaemic conditions and therefore could serve as a true functional food.