Artículos de revistas
Signature of consciousness in the dynamics of resting-state brain activity
Date
2015-01Registration in:
Barttfeld, Pablo; Uhrig, Lynn; Sitt, Jacobo Diego; Sigman, Mariano; Jarraya, Béchir; et al.; Signature of consciousness in the dynamics of resting-state brain activity; National Academy Of Sciences; Proceedings Of The National Academy Of Sciences Of The United States Of America; 112; 3; 1-2015; 887-892
0027-8424
CONICET Digital
CONICET
Author
Barttfeld, Pablo
Uhrig, Lynn
Sitt, Jacobo Diego
Sigman, Mariano
Jarraya, Béchir
Dehaene, Stanislas
Abstract
At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients.