Artículos de revistas
Carbon nanotubes buckypapers for potential transdermal drug delivery
Fecha
2015-07Registro en:
Schwengber, Alex; Prado, Héctor Juan; Zilli, Dario Adrian; Bonelli, Pablo Ricardo; Cukierman, Ana Lea; Carbon nanotubes buckypapers for potential transdermal drug delivery; Elsevier Science; Materials Science and Engineering: C; 57; 7-2015; 7-13
0928-4931
CONICET Digital
CONICET
Autor
Schwengber, Alex
Prado, Héctor Juan
Zilli, Dario Adrian
Bonelli, Pablo Ricardo
Cukierman, Ana Lea
Resumen
Drug loaded buckypapers based on different types of carbon nanotubes (CNTs) were prepared and characterized in order to evaluate their potentialities for the design of novel transdermal drug delivery systems. Lab-synthesized CNTs as well as commercial samples were employed. Clonidine hydrochloride was used as model drug, and the influence of composition of the drug loaded buckypapers and processing variables on in vitro release profiles was investigated. To examine the influence of the drug nature the evaluation was further extended to buckypapers prepared with flurbiprofen and one type of CNTs, their selection being based on the results obtained with the former drug. Scanning electronic microscopy images indicated that the model drugs were finely dispersed on the CNTs. Differential scanning calorimetry, and X-ray diffraction pointed to an amorphous state of both drugs in the buckypapers. A higher degree of CNT-drug superficial interactions resulted in a slower release of the drug. These interactions were in turn affected by the type of CNTs employed (single wall or multiwall CNTs), their functionalization with hydroxyl or carboxyl groups, the chemical structure of the drug, and the CNT:drug mass ratio. Furthermore, the application of a second layer of drug free CNTs on the loaded buckypaper, led to decelerate the drug release and to reduce the burst effect.