Artículos de revistas
Water versus DNA: New insights into proton track-structure modelling in radiobiology and radiotherapy
Fecha
2015-09Registro en:
Champion, C.; Quinto, Michele Arcangelo; Monti, Juan Manuel; Galassi, Mariel Elisa; Weck, P. F.; et al.; Water versus DNA: New insights into proton track-structure modelling in radiobiology and radiotherapy; IOP Publishing; Physics In Medicine And Biology; 60; 20; 9-2015; 7805-7828
0031-9155
CONICET Digital
CONICET
Autor
Champion, C.
Quinto, Michele Arcangelo
Monti, Juan Manuel
Galassi, Mariel Elisa
Weck, P. F.
Fojon, Omar Ariel
Hanssen, Jocelyn
Rivarola, Roberto Daniel
Resumen
Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence - expressed in terms of total cross sections - as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies.