dc.creator | Gonzalez, Maria Ines | |
dc.creator | Rubinstein, Natalia | |
dc.creator | Ilarregui, Juan Martin | |
dc.creator | Toscano, Marta Alicia | |
dc.creator | Sanjuan, Norberto Aníbal | |
dc.creator | Rabinovich, Gabriel Adrián | |
dc.date.accessioned | 2017-11-26T19:10:54Z | |
dc.date.accessioned | 2018-11-06T11:58:57Z | |
dc.date.available | 2017-11-26T19:10:54Z | |
dc.date.available | 2018-11-06T11:58:57Z | |
dc.date.created | 2017-11-26T19:10:54Z | |
dc.date.issued | 2005-10 | |
dc.identifier | Gonzalez, Maria Ines; Rubinstein, Natalia; Ilarregui, Juan Martin; Toscano, Marta Alicia; Sanjuan, Norberto Aníbal; et al.; Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis; Biolife Sas; International Journal Of Immunopathology And Pharmacology; 18; 4; 10-2005; 615-623 | |
dc.identifier | 0394-6320 | |
dc.identifier | http://hdl.handle.net/11336/29130 | |
dc.identifier | 2058-7384 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1861826 | |
dc.description.abstract | Apoptosis of cytotoxic T lymphocytes by herpes simplex virus type-1 (HSV-1) has been reported to be a relevant mechanism of viral immune evasion. Galectin-1 (Gal-1), an endogenous lectin involved in T-cell apoptosis, has recently gained considerable attention as a novel mechanism of tumor-immune evasion. Here we investigated whether infection of cells with HSV-1 can modulate the expression of Gal-1. Results show that pro-apoptotic Gal-1, but not Gal-3, is remarkably up-regulated in cell cultures infected with HSV-1. In addition, this protein is secreted to the extracellular milieu, where it contributes to apoptosis of activated T cells in a carbohydrate-dependent manner. Since many viruses have evolved mechanisms to counteract the antiviral response raised by the infected host, our results suggest that HSV-1 may use galectin-1 as a weapon to kill activated T cells and evade specific immune responses. | |
dc.language | eng | |
dc.publisher | Biolife Sas | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/abs/10.1177/039463200501800402 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/039463200501800402 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/16388708 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | HERPES SIMPLEX VIRUS I | |
dc.subject | APOPTOSIS | |
dc.subject | IMMUNE EVASION | |
dc.subject | GALECTIN-1 | |
dc.subject | GALECTIN-3 | |
dc.title | Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |