dc.creatorBergero, Paula Elena
dc.creatorFabricius, Gabriel
dc.creatorHozbor, Daniela Flavia
dc.creatorTheeten, Heidi
dc.creatorHens, Niel
dc.date.accessioned2018-06-08T18:45:48Z
dc.date.accessioned2018-11-06T11:57:07Z
dc.date.available2018-06-08T18:45:48Z
dc.date.available2018-11-06T11:57:07Z
dc.date.created2018-06-08T18:45:48Z
dc.date.issued2018-02
dc.identifierBergero, Paula Elena; Fabricius, Gabriel; Hozbor, Daniela Flavia; Theeten, Heidi; Hens, Niel; Potential Impact of Changes in the Schedule for Primary Diphtheria-Tetanus Toxoids-Pertussis Immunization as Control Strategy for Pertussis; Lippincott Williams; Pediatric Infectious Disease Journal; 37; 2; 2-2018; e36-e42
dc.identifier0891-3668
dc.identifierhttp://hdl.handle.net/11336/47928
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1861443
dc.description.abstractBackground: Pertussis is a vaccine-preventable respiratory disease that may cause death mainly in infants. The schedules for primary pertussis vaccination are set in each country by the local health authorities. Several different schedules meet World Health Organization recommendations, 2–4–6 months, 6–10–14 weeks, 2–3–4 months and 3–4–5 months being the most commonly used worldwide. In this work, we analyze the benefits of changing the vaccination schedule to control the disease. Methods: We used an age-structured deterministic mathematical model for pertussis transmission to compute the incidences for the 4 above-mentioned schedules. Different vaccination coverages and vaccine effectiveness levels were considered. Immunization data from Argentina and Belgium were used. Results: The highest reduction in incidence was obtained by adopting the 6–10–14 weeks schedule, reaching about a 36% reduction of 0–1-year incidence with respect to the 2–4–6 months schedule. We show the dependence of this reduction on both vaccine effectiveness and coverage. The severe pertussis incidence decreased significantly when the first dose of the 2–4–6 months schedule was accelerated to 6 weeks. Finally, we estimated that the communication campaign adopted in Flanders (Belgium) to improve compliance with the vaccine schedule could lead to a reduction of 16% in severe pertussis incidence and about 7% in total incidence in infants. Conclusions: Our work highlights the use of mathematical modeling to quantify the benefits of the existing vaccination schedules and the strategies that could be implemented to improve their compliance. Our results indicated that the 6–10–14 weeks is the best schedule option and that the Belgium vaccination campaign significantly reduced the incidence of severe cases.
dc.languageeng
dc.publisherLippincott Williams
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1097/INF.0000000000001752
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00006454-201802000-00018
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPertussis
dc.subjectschedules
dc.subjectmathematical model
dc.subjectepidemiology
dc.titlePotential Impact of Changes in the Schedule for Primary Diphtheria-Tetanus Toxoids-Pertussis Immunization as Control Strategy for Pertussis
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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