Regulation of spine density and morphology by IQGAP1 protein domains

dc.creatorJausoro, Ignacio
dc.creatorMestres Lascano, Ivan
dc.creatorQuassollo Infanzon, Gonzalo Emiliano
dc.creatorMasseroni, Maria Luján
dc.creatorHeredia, María Florencia
dc.creatorCaceres, Alfredo Oscar
dc.date.accessioned2015-06-04T19:03:15Z
dc.date.accessioned2018-11-06T11:55:18Z
dc.date.available2015-06-04T19:03:15Z
dc.date.available2018-11-06T11:55:18Z
dc.date.created2015-06-04T19:03:15Z
dc.date.issued2013-02
dc.identifierJausoro, Ignacio; Mestres Lascano, Ivan; Quassollo Infanzon, Gonzalo Emiliano; Masseroni, Maria Luján; Heredia, María Florencia; Caceres, Alfredo Oscar; Regulation of spine density and morphology by IQGAP1 protein domains; Public Library Science; Plos One; 8; 2; 2-2013; e56574;
dc.identifier1932-6203
dc.identifierhttp://hdl.handle.net/11336/604
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1861056
dc.description.abstractIQGAP1 is a scaffolding protein that regulates spine number. We now show a differential role for IQGAP1 domains in spine morphogenesis, in which a region of the N-terminus that promotes Arp2/3-mediated actin polymerization and branching stimulates spine head formation while a region that binds to Cdc42 and Rac is required for stalk extension. Conversely, IQGAP1 rescues spine deficiency induced by expression of dominant negative Cdc42 by stimulating formation of stubby spines. Together, our observations place IQGAP1 as a crucial regulator of spine number and shape acting through the N-Wasp Arp2/3 complex, as well as upstream and downstream of Cdc42.
dc.languageeng
dc.publisherPublic Library Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0056574
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIQGAP
dc.subjectNEURON
dc.subjectSPINES
dc.titleRegulation of spine density and morphology by IQGAP1 protein domains
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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