Artículos de revistas
Sauroine, an alkaloid from Huperzia saururus with activity in wistar rats in electrophysiological and behavioral assays related to memory retention
Fecha
2009-12Registro en:
Vallejo, Mariana Guadalupe; Ortega, María Gabriela; Cabrera, Jose Luis; Carlini, Valeria Paola; Rubiales, Susana Elizabeth; et al.; Sauroine, an alkaloid from Huperzia saururus with activity in wistar rats in electrophysiological and behavioral assays related to memory retention; American Chemical Society; Journal of Natural Products; 72; 1; 12-2009; 156-158
0163-3864
CONICET Digital
CONICET
Autor
Vallejo, Mariana Guadalupe
Ortega, María Gabriela
Cabrera, Jose Luis
Carlini, Valeria Paola
Rubiales, Susana Elizabeth
Almiron, Romina Soledad
Ramirez, Oscar Angel
Agnese, Alicia Mariel
Resumen
The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed on male Wistar rats. The results showed that 1 improved memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus, 1 seems to be a constituent responsible for the activity claimed in folk medicine for H. saururus in Argentina.