dc.creator | López Ordieres, María Graciela | |
dc.creator | Rodriguez, Georgina Emma | |
dc.date.accessioned | 2017-05-31T16:49:11Z | |
dc.date.accessioned | 2018-11-06T11:53:23Z | |
dc.date.available | 2017-05-31T16:49:11Z | |
dc.date.available | 2018-11-06T11:53:23Z | |
dc.date.created | 2017-05-31T16:49:11Z | |
dc.date.issued | 2014-01 | |
dc.identifier | López Ordieres, María Graciela; Rodriguez, Georgina Emma; Kinectics of Na+, K+-ATPase inhibition by calcitonin and neurotensin; Research Trends; Current Topics in Peptide & Protein Research; 15; 1-2014; 63-70 | |
dc.identifier | 0972-4524 | |
dc.identifier | http://hdl.handle.net/11336/17157 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1860662 | |
dc.description.abstract | The kinetics of interactions between the peptides calcitonin or neurotensin, and synaptosomal membrane Na+, K+-ATPase activity was characterized in this study. Calcitonin is a 32-amino acid peptide produced by the thyroid gland, whose main role is to prevent bone resorption. Calcitonin produced a non-competitive type of inhibition at varied potassium concentrations whereas in the presence of sodium and ATP, calcitonin produced an uncompetitive and competitive type of inhibition, respectively. Neurotensin is a basic tridecapeptide which also inhibits Na+, K+-ATPase activity. Therefore, in the presence of higher sodium concentrations the peptide produced a competitive interaction and it produced a non-competitive type of inhibition at varied potassium and ATP concentrations. In summary, calcitonin and neutotensin behave as enzyme inhibitors but, each one leads to a characteristic type of enzyme inhibition at varied substrate concentrations due to differences in peptide structure and functionality that could be influencing the kinetics of substrate interactions. | |
dc.language | eng | |
dc.publisher | Research Trends | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=15&tid=26&aid=5651&pub=2014&type=3 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | CALCITONIN | |
dc.subject | NEUROTENSIN | |
dc.subject | ATPase | |
dc.subject | INHIBITION | |
dc.title | Kinectics of Na+, K+-ATPase inhibition by calcitonin and neurotensin | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |