Chronic Pregabalin Treatment Decreases Excitability of Dentate Gyrus and Accelerates Maturation of Adult-born Granule Cells

dc.creatorLempel, Augusto Abel
dc.creatorColl, Lucia
dc.creatorSchinder, Alejandro Fabián
dc.creatorUchitel, Osvaldo Daniel
dc.creatorPiriz, Joaquin
dc.date.accessioned2018-06-05T21:12:44Z
dc.date.accessioned2018-11-06T11:52:13Z
dc.date.available2018-06-05T21:12:44Z
dc.date.available2018-11-06T11:52:13Z
dc.date.created2018-06-05T21:12:44Z
dc.date.issued2017-01
dc.identifierLempel, Augusto Abel; Coll, Lucia; Schinder, Alejandro Fabián; Uchitel, Osvaldo Daniel; Piriz, Joaquin; Chronic Pregabalin Treatment Decreases Excitability of Dentate Gyrus and Accelerates Maturation of Adult-born Granule Cells; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 140; 2; 1-2017; 257-267
dc.identifier0022-3042
dc.identifierhttp://hdl.handle.net/11336/47422
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1860429
dc.description.abstractPregabalin (PGB) is extensively prescribed to treat neurological andneuropsychiatrical conditions such as neuropathic pain, anxiety disorders and epilepsy.Although PGB is known to bind selectively to the α2δ subunit of voltage gated calciumchannels, there is little understanding about how it exerts its therapeutic effects. In thisarticle we analyzed the effects of an in vivo chronic treatment with PGB over thephysiology of dentate gyrus granule cells (DGGCs) using ex vivo electrophysiological andmorphological analysis in adult mice. We found that PGB decreases neuronal excitabilityof DGGCs. In addition, PGB accelerates maturation of adult-born DGGCs, an effect thatwould modify dentate gyrus plasticity. Together, these findings suggest that PGB reducesactivity in the dentate gyrus and modulates overall network plasticity, which mightcontribute to its therapeutic effects
dc.languageeng
dc.publisherWiley Blackwell Publishing, Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jnc.13740
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.13740
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDENTATE GYRUS
dc.subjectNEUROGENESIS
dc.subjectPREGABALIN
dc.subjectGABAPENTIN
dc.titleChronic Pregabalin Treatment Decreases Excitability of Dentate Gyrus and Accelerates Maturation of Adult-born Granule Cells
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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