Discovery of a new class of non-â-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity and oral bioavailability

dc.creatorO’Daniel, Peter I.
dc.creatorPeng, Zhihong
dc.creatorPi, Hualiang
dc.creatorTestero, Sebastian Andres
dc.creatorDing, Derong
dc.creatorSpink, Edward
dc.creatorLeemans, Erika J.
dc.creatorBoudreau, Marc A.
dc.creatorYamaguchi, Takao
dc.creatorSchroeder, Valerie A
dc.creatorWolter, William R.
dc.creatorLlarrull, Leticia Irene
dc.creatorSong, Wei
dc.creatorLashtochkin, Elena
dc.creatorShi, Qicun
dc.creatorKumarasiri, Malika
dc.creatorAntunes, Nuno T.
dc.creatorEspahbodi, Mana
dc.creatorLichtenwalter, Katerina
dc.creatorSuckow, Mark A.
dc.creatorVakulenko, Sergei
dc.creatorMobashery, Shahriar
dc.creatorChang, Mayland
dc.date.accessioned2017-12-21T15:32:45Z
dc.date.available2017-12-21T15:32:45Z
dc.date.created2017-12-21T15:32:45Z
dc.date.issued2014-02
dc.identifierO’Daniel, Peter I.; Peng, Zhihong; Pi, Hualiang; Testero, Sebastian Andres; Ding, Derong; et al.; Discovery of a new class of non-â-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity and oral bioavailability; American Chemical Society; Journal of the American Chemical Society; 136; 2-2014; 3664-3672
dc.identifier0002-7863
dc.identifierhttp://hdl.handle.net/11336/31218
dc.identifierCONICET Digital
dc.identifierCONICET
dc.description.abstractInfections caused by hard-to-treat methicillin-resistantStaphylococcus aureus(MRSA) are a serious global public-health concern,as MRSA has become broadly resistant to many classes of antibiotics. Wedisclose herein the discovery of a new class of non-β-lactam antibiotics,the oxadiazoles, which inhibit penicillin-binding protein 2a (PBP2a) ofMRSA. The oxadiazoles show bactericidal activity against vancomycin-and linezolid-resistant MRSA and other Gram-positive bacterial strains,invivoefficacy in a mouse model of infection, and have 100% oralbioavailability.
dc.languageeng
dc.publisherAmerican Chemical Society
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/ja500053x
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/ja500053x
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibiotics
dc.subjectMrsa
dc.subjectOxadiazoles
dc.subjectPenicillin Binding Proteins
dc.titleDiscovery of a new class of non-â-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity and oral bioavailability
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución