dc.creator | Marcone, Débora Natalia | |
dc.creator | Culasso, Andrés Carlos Alberto | |
dc.creator | Carballal, Guadalupe | |
dc.creator | Campos, Rodolfo Hector | |
dc.creator | Echavarría, Marcela Silvia | |
dc.date.accessioned | 2017-12-13T18:08:47Z | |
dc.date.available | 2017-12-13T18:08:47Z | |
dc.date.created | 2017-12-13T18:08:47Z | |
dc.date.issued | 2014-10 | |
dc.identifier | Marcone, Débora Natalia; Culasso, Andrés Carlos Alberto; Carballal, Guadalupe; Campos, Rodolfo Hector; Echavarría, Marcela Silvia; Genetic diversity and clinical impact of human rhinoviruses in hospitalized and outpatient children with acute respiratory infection, Argentina; Elsevier; Journal of Clinical Virology; 61; 4; 10-2014; 558-564 | |
dc.identifier | 1386-6532 | |
dc.identifier | http://hdl.handle.net/11336/30483 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.description.abstract | BACKGROUND: Human rhinoviruses (HRV) are recognized as a cause of upper and lower acute respiratory infections (ARI). The circulating species and their clinical impact were not described in Argentina.
OBJECTIVES: To describe the molecular epidemiology of HRV in children and to determine the association of HRV species with outcome and severity.
STUDY DESIGN: Hospitalized and outpatients children <6 years old with ARI without comorbidities (n=620) were enrolled (2008-2010). Demographic, clinical data and outcome were analyzed. HRV were identified by RT-PCR. Phylogenetic analysis and demographic reconstruction for HRV were performed in selected samples.
RESULTS: HRV were detected in 252/620 (40.6%) of children; 8.5% in viral coinfection. Bronchiolitis (55%) and pneumonia (13%) were the most frequent clinical diagnosis. Of 202 inpatients with HRV: 72% required oxygen supplementation, 11% intensive care unit and 3% mechanical ventilation. HRV were identified as a risk factor for hospitalization (OR: 2.47). All three HRV species were detected being HRV-A (55%) and HRV-C (43%) the most frequent; HRV-B was infrequent (2%). Of 44 sequenced HRV, 30 genotypes were detected. Seven of them were the most prevalent and circulated during limited periods of time. The demographic reconstruction revealed a constant population size and a high turnover rate of genotypes. Demographic and clinical outcome were similar for HRV-A and HRV-C infections.
CONCLUSION: This study highlights the clinical impact of HRV in children without comorbidities as a cause of lower ARI and hospitalization. The high frequency of HRV infections may be associated with the simultaneous circulation of genotypes and their high turnover rate. | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jcv.2014.10.006 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/www.sciencedirect.com/science/article/pii/S138665321400376X | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | Human Rhinoviruses | |
dc.subject | Genotypes | |
dc.subject | Acute Respiratory Infection | |
dc.subject | Children | |
dc.subject | Molecular Epidemiology | |
dc.title | Genetic diversity and clinical impact of human rhinoviruses in hospitalized and outpatient children with acute respiratory infection, Argentina | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |