dc.creator | Hein, Gustavo Juan | |
dc.creator | Baker, Chris | |
dc.creator | Hsieh, Joanne | |
dc.creator | Farr, Sara | |
dc.creator | Khosrow, Adeli | |
dc.date.accessioned | 2017-05-11T20:23:19Z | |
dc.date.accessioned | 2018-11-06T11:41:21Z | |
dc.date.available | 2017-05-11T20:23:19Z | |
dc.date.available | 2018-11-06T11:41:21Z | |
dc.date.created | 2017-05-11T20:23:19Z | |
dc.date.issued | 2013-06 | |
dc.identifier | Hein, Gustavo Juan; Baker, Chris; Hsieh, Joanne; Farr, Sara; Khosrow, Adeli; GLP-1 and GLP-2 as Ying and Yang of Intestinal Lipoprotein Production: Evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin Resistant States; American Diabetes Association; Diabetes; 62; 2; 6-2013; 373-381 | |
dc.identifier | 0012-1797 | |
dc.identifier | http://hdl.handle.net/11336/16339 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1857700 | |
dc.description.abstract | The glucagon-like peptides (GLP-1 and GLP-2) are processed from the proglucagon polypeptide and secreted in equimolar amounts but have opposite effects on chylomicron (CM) production, with GLP-1 significantly reducing and GLP-2 increasing postprandial chylomicronemia. In the current study, we evaluated the apparent paradoxical roles of GLP-1 and GLP-2 under physiological conditions in the Syrian golden hamster, a model with close similarity to humans in terms of lipoprotein metabolism. A short (30-min) intravenous infusion of GLP-2 resulted in a marked increase in postprandial apolipoprotein B48 (apoB48) and triglyceride (TG) levels in the TG-rich lipoprotein (TRL) fraction, whereas GLP-1 infusion decreased lipid absorption and levels of TRL-TG and apoB48. GLP-1 and GLP-2 coinfusion resulted in net increased lipid absorption and an increase in TRL-TG and apoB48. However, prolonged (120-min) coinfusion of GLP-1 and GLP-2 decreased postprandial lipemia. Blocking dipeptidyl peptidase-4 activity resulted in decreased postprandial lipemia. Interestingly, fructose-fed, insulin-resistant hamsters showed a more pronounced response, including possible hypersensitivity to GLP-2 or reduced sensitivity to GLP-1. In conclusion, under normal physiological conditions, the actions of GLP-2 predominate; however, when GLP-1 activity is sustained, the hypolipidemic action of GLP-1 predominates. Pharmacological inhibition of GLP-1 degradation tips the balance toward an inhibitory effect on intestinal production of atherogenic CM particles. | |
dc.language | eng | |
dc.publisher | American Diabetes Association | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://diabetes.diabetesjournals.org/content/early/2012/09/19/db12-0202.abstract | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2337/db12-0202 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | Apolipoprotein B | |
dc.subject | Chylomicrons | |
dc.subject | Glucagon-like peptide | |
dc.subject | Dipeptidyl peptidase-4 | |
dc.title | GLP-1 and GLP-2 as Ying and Yang of Intestinal Lipoprotein Production: Evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin Resistant States | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |