dc.creatorHein, Gustavo Juan
dc.creatorBaker, Chris
dc.creatorHsieh, Joanne
dc.creatorFarr, Sara
dc.creatorKhosrow, Adeli
dc.date.accessioned2017-05-11T20:23:19Z
dc.date.accessioned2018-11-06T11:41:21Z
dc.date.available2017-05-11T20:23:19Z
dc.date.available2018-11-06T11:41:21Z
dc.date.created2017-05-11T20:23:19Z
dc.date.issued2013-06
dc.identifierHein, Gustavo Juan; Baker, Chris; Hsieh, Joanne; Farr, Sara; Khosrow, Adeli; GLP-1 and GLP-2 as Ying and Yang of Intestinal Lipoprotein Production: Evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin Resistant States; American Diabetes Association; Diabetes; 62; 2; 6-2013; 373-381
dc.identifier0012-1797
dc.identifierhttp://hdl.handle.net/11336/16339
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1857700
dc.description.abstractThe glucagon-like peptides (GLP-1 and GLP-2) are processed from the proglucagon polypeptide and secreted in equimolar amounts but have opposite effects on chylomicron (CM) production, with GLP-1 significantly reducing and GLP-2 increasing postprandial chylomicronemia. In the current study, we evaluated the apparent paradoxical roles of GLP-1 and GLP-2 under physiological conditions in the Syrian golden hamster, a model with close similarity to humans in terms of lipoprotein metabolism. A short (30-min) intravenous infusion of GLP-2 resulted in a marked increase in postprandial apolipoprotein B48 (apoB48) and triglyceride (TG) levels in the TG-rich lipoprotein (TRL) fraction, whereas GLP-1 infusion decreased lipid absorption and levels of TRL-TG and apoB48. GLP-1 and GLP-2 coinfusion resulted in net increased lipid absorption and an increase in TRL-TG and apoB48. However, prolonged (120-min) coinfusion of GLP-1 and GLP-2 decreased postprandial lipemia. Blocking dipeptidyl peptidase-4 activity resulted in decreased postprandial lipemia. Interestingly, fructose-fed, insulin-resistant hamsters showed a more pronounced response, including possible hypersensitivity to GLP-2 or reduced sensitivity to GLP-1. In conclusion, under normal physiological conditions, the actions of GLP-2 predominate; however, when GLP-1 activity is sustained, the hypolipidemic action of GLP-1 predominates. Pharmacological inhibition of GLP-1 degradation tips the balance toward an inhibitory effect on intestinal production of atherogenic CM particles.
dc.languageeng
dc.publisherAmerican Diabetes Association
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://diabetes.diabetesjournals.org/content/early/2012/09/19/db12-0202.abstract
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2337/db12-0202
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectApolipoprotein B
dc.subjectChylomicrons
dc.subjectGlucagon-like peptide
dc.subjectDipeptidyl peptidase-4
dc.titleGLP-1 and GLP-2 as Ying and Yang of Intestinal Lipoprotein Production: Evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin Resistant States
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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