dc.creator | Badano, Ines | |
dc.creator | Schurr, T. G. | |
dc.creator | Stietz, S. M. | |
dc.creator | Dulik, M. C. | |
dc.creator | Mampaey, M. | |
dc.creator | Quintero, I. M. | |
dc.creator | Zinovich, J. B. | |
dc.creator | Campos, Rodolfo Hector | |
dc.creator | Liotta, Domingo Javier | |
dc.date.accessioned | 2015-09-10T14:55:30Z | |
dc.date.accessioned | 2018-11-06T11:40:04Z | |
dc.date.available | 2015-09-10T14:55:30Z | |
dc.date.available | 2018-11-06T11:40:04Z | |
dc.date.created | 2015-09-10T14:55:30Z | |
dc.date.issued | 2013-06 | |
dc.identifier | Badano, Ines; Schurr, T. G.; Stietz, S. M.; Dulik, M. C.; Mampaey, M.; et al.; TNF promoter SNP variation in Amerindians and white-admixed women from Misiones, Argentina; Wiley; International Journal of Immunogenetics; 40; 3; 6-2013; 216-221 | |
dc.identifier | 1744-313X | |
dc.identifier | http://hdl.handle.net/11336/1994 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1857247 | |
dc.description.abstract | The aim of this study is to describe genetic variation in the TNF promoter in the ethnically diverse population of Misiones, north-eastern Argentina. We analysed 210 women including 66 Amerindians of the Mbya-Guarani ethnic group and 144 white-admixed individuals from urban and rural areas of Misiones. Their DNA samples were surveyed for TNF polymorphisms -376 A/G, -308 A/G -244 A/G and -238 A/G by PCR amplification and direct sequencing and for the Amerindian marker -857 C/T by real-time PCR. Our main findings are as follows:(i) a distinctive pattern of Single Nucleotide Polymorphism (SNP) distribution among these groups, (ii) genetic differentiation between the Mbya-Guarani and the white-admixed populations (P < 0.05), (iii) lower gene diversity (~0.05) in Mbya-Guarani compared with the whiteadmixed group (~0.21); and (iv) linkage disequilibrium between the -376A and -238A SNPs in white-admixed populations. These data highlight the principal role of population history in establishing present-day genetic variation at the TNF locus and provide a framework for undertaking ethnographic and disease association studies in Misiones. | |
dc.language | eng | |
dc.publisher | Wiley | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/iji.12002/abstract | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/DOI:10.1111/iji.12002 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | TNF promoter | |
dc.subject | SNP variation | |
dc.subject | Amerindians and white-admixed women | |
dc.subject | Misiones Argentina | |
dc.title | TNF promoter SNP variation in Amerindians and white-admixed women from Misiones, Argentina | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |