dc.creatorDi Venosa, Gabriela Mariana
dc.creatorPerotti, Christian
dc.creatorBatlle, Alcira Maria del C.
dc.creatorCasas, Adriana Gabriela
dc.date.accessioned2017-03-08T17:59:16Z
dc.date.available2017-03-08T17:59:16Z
dc.date.created2017-03-08T17:59:16Z
dc.date.issued2015-04
dc.identifierDi Venosa, Gabriela Mariana; Perotti, Christian; Batlle, Alcira Maria del C.; Casas, Adriana Gabriela; The role of cytoskeleton and adhesion proteins in the resistance to photodynamic therapy: possible therapeutic interventions; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 14; 8; 4-2015; 1451-1464
dc.identifier1474-905X
dc.identifierhttp://hdl.handle.net/11336/13633
dc.identifier1474-9092
dc.description.abstractIt is known that Photodynamic Therapy (PDT) induces changes in the cytoskeleton, the cell shape, and the adhesion properties of tumour cells. In addition, these targets have also been demonstrated to be involved in the development of PDT resistance. The reversal of PDT resistance by manipulating the cell adhesion process to substrata has been out of reach. Even though the existence of cell adhesion-mediated PDT resistance has not been reported so far, it cannot be ruled out. In addition to its impact on the apoptotic response to photodamage, the cytoskeleton alterations are thought to be associated with the processes of metastasis and invasion after PDT. In this review, we will address the impact of photodamage on the microfilament and microtubule cytoskeleton components and its regulators on PDT-treated cells as well as on cell adhesion. We will also summarise the impact of PDT on the surviving and resistant cells and their metastatic potential. Possible strategies aimed at taking advantage of the changes induced by PDT on actin, tubulin and cell adhesion proteins by targeting these molecules will also be discussed.
dc.languageeng
dc.publisherRoyal Society of Chemistry
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/content/articlelanding/2015/pp/c4pp00445k#!divAbstract
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/C4PP00445K
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytoskeleton
dc.subjectAdhesion Proteins
dc.subjectPhotodynamic Therapy
dc.titleThe role of cytoskeleton and adhesion proteins in the resistance to photodynamic therapy: possible therapeutic interventions
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución