Synthesis and micellization properties of triblock copolymers PDMAEMA-b-PCL-b-PDMAEMA and their applications in the fabrication of amphotericin B-loaded nanocontainers

dc.creatorDiaz Ariza, Ivonne Lorena
dc.creatorPerez, Leon D.
dc.date.accessioned2017-06-07T21:07:12Z
dc.date.accessioned2018-11-06T11:31:34Z
dc.date.available2017-06-07T21:07:12Z
dc.date.available2018-11-06T11:31:34Z
dc.date.created2017-06-07T21:07:12Z
dc.date.issued2015-03
dc.identifierDiaz Ariza, Ivonne Lorena; Perez, Leon D.; Synthesis and micellization properties of triblock copolymers PDMAEMA-b-PCL-b-PDMAEMA and their applications in the fabrication of amphotericin B-loaded nanocontainers; Springer Heidelberg; Colloid And Polymer Science; 293; 3; 3-2015; 913-923
dc.identifier0303-402X
dc.identifierhttp://hdl.handle.net/11336/17716
dc.identifier1435-1536
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1854160
dc.description.abstractIn this study, we report the synthesis of PDMAEMA-b-PCL-b-PDMAEMA via ATRP starting from two dibromide-end polycaprolactone (PCL) of 2 and 10 kDa. The copolymerization was confirmed by nuclear magnetic resonance and gel permeation chromatography. The micellar properties of copolymers with different compositions were studied at pH 5.0, 6.0, 7.0, and 7.5. According to results, properties such as critical micellar concentration (CMC), hydrophobicity of micelle cores, and particle size strongly depend on the length of PCL. The pH shows an important effect on the size of the colloidal aggregates. Micelles obtained from copolymers with the lowest polymerization degree of both segments showed to be more appropriate for the encapsulation of amphotericin B (AmB).
dc.languageeng
dc.publisherSpringer Heidelberg
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00396-014-3478-3
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00396-014-3478-3
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPOLYCAPROLACTONE
dc.subjectBLOCK COPOLYMER
dc.subjectMICELLES
dc.subjectATOM TRANSFERENCE RADICAL POLYMERIZATION
dc.titleSynthesis and micellization properties of triblock copolymers PDMAEMA-b-PCL-b-PDMAEMA and their applications in the fabrication of amphotericin B-loaded nanocontainers
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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