dc.creator | Huetteroth, Wolf | |
dc.creator | Perisse, Emmanuel | |
dc.creator | Lin, Suewei | |
dc.creator | Klappenbach, Martín | |
dc.creator | Burke, Christopher | |
dc.creator | Waddell, Scott | |
dc.date.accessioned | 2018-03-08T20:28:19Z | |
dc.date.accessioned | 2018-11-06T11:30:53Z | |
dc.date.available | 2018-03-08T20:28:19Z | |
dc.date.available | 2018-11-06T11:30:53Z | |
dc.date.created | 2018-03-08T20:28:19Z | |
dc.date.issued | 2015-03 | |
dc.identifier | Huetteroth, Wolf; Perisse, Emmanuel; Lin, Suewei; Klappenbach, Martín; Burke, Christopher; et al.; Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila; Cell Press; Current Biology; 25; 6; 3-2015; 751-758 | |
dc.identifier | 0960-9822 | |
dc.identifier | http://hdl.handle.net/11336/38320 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1853865 | |
dc.description.abstract | Dopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the β′2 and γ4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ5b regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population. | |
dc.language | eng | |
dc.publisher | Cell Press | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cub.2015.01.036 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982215000688 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Dopamine | |
dc.subject | Reward | |
dc.subject | Drosophila | |
dc.title | Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |