dc.creatorHuetteroth, Wolf
dc.creatorPerisse, Emmanuel
dc.creatorLin, Suewei
dc.creatorKlappenbach, Martín
dc.creatorBurke, Christopher
dc.creatorWaddell, Scott
dc.date.accessioned2018-03-08T20:28:19Z
dc.date.accessioned2018-11-06T11:30:53Z
dc.date.available2018-03-08T20:28:19Z
dc.date.available2018-11-06T11:30:53Z
dc.date.created2018-03-08T20:28:19Z
dc.date.issued2015-03
dc.identifierHuetteroth, Wolf; Perisse, Emmanuel; Lin, Suewei; Klappenbach, Martín; Burke, Christopher; et al.; Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila; Cell Press; Current Biology; 25; 6; 3-2015; 751-758
dc.identifier0960-9822
dc.identifierhttp://hdl.handle.net/11336/38320
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1853865
dc.description.abstractDopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the β′2 and γ4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ5b regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population.
dc.languageeng
dc.publisherCell Press
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cub.2015.01.036
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982215000688
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDopamine
dc.subjectReward
dc.subjectDrosophila
dc.titleSweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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