dc.creator | Matarrese, Paola | |
dc.creator | Tinari, Antonella | |
dc.creator | Mormone, Elisabetta | |
dc.creator | Bianco, German Ariel | |
dc.creator | Toscano, Marta Alicia | |
dc.creator | Ascione, Barbara | |
dc.creator | Rabinovich, Gabriel Adrián | |
dc.creator | Malorni, Walter | |
dc.date.accessioned | 2017-12-22T05:26:53Z | |
dc.date.accessioned | 2018-11-06T11:30:48Z | |
dc.date.available | 2017-12-22T05:26:53Z | |
dc.date.available | 2018-11-06T11:30:48Z | |
dc.date.created | 2017-12-22T05:26:53Z | |
dc.date.issued | 2005-11-19 | |
dc.identifier | Malorni, Walter; Rabinovich, Gabriel Adrián; Ascione, Barbara; Toscano, Marta Alicia; Bianco, German Ariel; Mormone, Elisabetta; et al.; Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission.; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 280; 8; 19-11-2005; 6969-6985 | |
dc.identifier | 0021-9258 | |
dc.identifier | http://hdl.handle.net/11336/31343 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1853827 | |
dc.description.abstract | Galectins have emerged as a novel family of immunoregulatory proteins implicated in T cell homeostasis. Recent studies showed that galectin-1 (Gal-1) plays a key role in tumor-immune escape by killing antitumor effector T cells. Here we found that Gal-1 sensitizes human resting T cells to Fas (CD95)/caspase-8-mediated cell death. Furthermore, this protein triggers an apoptotic program involving an increase of mitochondrial membrane potential and participation of the ceramide pathway. In addition, Gal-1 induces mitochondrial coalescence, budding, and fission accompanied by an increase and/or redistribution of fission-associated molecules h-Fis and DRP-1. Importantly, these changes are detected in both resting and activated human T cells, suggesting that Gal-1-induced cell death might become an excellent model to analyze the morphogenetic changes of mitochondria during the execution of cell death. This is the first association among Gal-1, Fas/Fas ligand-mediated cell death, and the mitochondrial pathway, providing a rational basis for the immunoregulatory properties of Gal-1 in experimental models of chronic inflammation and cancer. | |
dc.language | eng | |
dc.publisher | American Society for Biochemistry and Molecular Biology | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/280/8/6969.long | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1074/jbc.M409752200 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/15556941 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | GALECTIN-1 | |
dc.subject | CANCER | |
dc.subject | APOPTOSIS | |
dc.subject | MITOCHONDRIA | |
dc.subject | T-LYMPHOCYTES | |
dc.title | Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |