Artículos de revistas
Genetically modified mouse models in studies of luteinising hormone action
Fecha
2006-06-27Registro en:
Huhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; et al.; Genetically modified mouse models in studies of luteinising hormone action; Elsevier Ireland; Molecular And Cellular Endocrinology; 252; 1-2; 27-6-2006; 126-135
0303-7207
1872-8057
CONICET Digital
CONICET
Autor
Huhtaniemi, Ilpo
Ahtiainen, Petteri
Pakarainen, Tomi
Rulli, Susana Beatriz
Zhang, Fu Ping
Poutanen, Mattu
Resumen
Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+).