dc.creator | Morande, Pablo Elías | |
dc.creator | Borge, Mercedes | |
dc.creator | Abreu, Cecilia | |
dc.creator | Galletti, Jeremías Gastón | |
dc.creator | Zanetti, Samanta Romina | |
dc.creator | Nannini, Paula Romina | |
dc.creator | Bezares, Fernando Raimundo | |
dc.creator | Pantano, Sergio | |
dc.creator | Dighiero, Guillermo | |
dc.creator | Oppezzo, Pablo | |
dc.creator | Gamberale, Romina | |
dc.creator | Giordano, Mirta Nilda | |
dc.date.accessioned | 2016-10-26T21:25:07Z | |
dc.date.accessioned | 2018-11-06T11:23:05Z | |
dc.date.available | 2016-10-26T21:25:07Z | |
dc.date.available | 2018-11-06T11:23:05Z | |
dc.date.created | 2016-10-26T21:25:07Z | |
dc.date.issued | 2015-01 | |
dc.identifier | Morande, Pablo Elías; Borge, Mercedes; Abreu, Cecilia; Galletti, Jeremías Gastón; Zanetti, Samanta Romina; et al.; Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi; Taylor & Francis; Leukemia And Lymphoma; 56; 4; 1-2015; 1-8 | |
dc.identifier | 1042-8194 | |
dc.identifier | http://hdl.handle.net/11336/7811 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1850196 | |
dc.description.abstract | Chronic lymphocytic leukemia (CLL) is the main cause of autoimmune hemolytic anemia (AHA). However, the cellular basis underlying this strong association remains unclear. We previously demonstrated that leukemic B cells from patients with CLL recognize the erythrocyte protein Band 3, a prevalent autoantigen in AHA. Here we show that the major binding site of Band 3 on leukemic cells is an extrinsic protein identified as high-mobility group nucleosome binding protein 2 (HMGN2), a nucleosome-interacting factor which has not been previously reported at the cell surface. T lymphocytes do not express HMGN2 or bind Band 3. Removal of HMGN2 from the cell membrane abrogated the capacity of Band 3-pulsed CLL cells to induce CD4 + T cell proliferation. We conclude that surface HMGN2 in leukemic B cells is involved in Band 3 binding, uptake and presentation to CD4 + T lymphocytes, and as such may favor the initiation of AHA secondary to CLL. | |
dc.language | eng | |
dc.publisher | Taylor & Francis | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10428194.2014.957205 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/10428194.2014.957205 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | AUTOIMMUNE HEMOLYTIC ANEMIA | |
dc.subject | CHRONIC LYMPHOCYTIC LEUKEMIA | |
dc.subject | HMGN2 | |
dc.title | Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |