dc.creator | Goldstein Raij, Jorge | |
dc.creator | Carden, Tomas Roberto | |
dc.creator | Perez, María J. | |
dc.creator | Taira, Carlos Alberto | |
dc.creator | Höcht, Christian | |
dc.creator | Gironacci, Mariela Mercedes | |
dc.date.accessioned | 2018-06-05T21:51:18Z | |
dc.date.accessioned | 2018-11-06T11:19:52Z | |
dc.date.available | 2018-06-05T21:51:18Z | |
dc.date.available | 2018-11-06T11:19:52Z | |
dc.date.created | 2018-06-05T21:51:18Z | |
dc.date.issued | 2016-12 | |
dc.identifier | Goldstein Raij, Jorge; Carden, Tomas Roberto; Perez, María J.; Taira, Carlos Alberto; Höcht, Christian; et al.; Angiotensin-(1–7) protects from brain damage induced by shiga toxin 2-producing enterohemorrhagic Escherichia coli; American Physiological Society; American Journal Of Physiology-regulatory, Integrative And Comparative Physiology; 311; 6; 12-2016; 1173-1185 | |
dc.identifier | 0363-6119 | |
dc.identifier | http://hdl.handle.net/11336/47423 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1848596 | |
dc.description.abstract | Shiga toxin 2 (Stx2)-producing enterohemorrhagic induced brain damage. Since a cerebroprotective action was reported for angiotensin (Ang)-(1–7), our aim was to investigate whether Ang-(1–7) protects from brain damage induced by Stx2-producing enterohemorrhagic Escherichia coli. The anterior hypothalamic area of adult male Wistar rats was injected with saline solution or Stx2 or Stx2 plus Ang-(1–7) or Stx2 plus Ang-(1–7) plus A779. Rats received a single injection of Stx2 at the beginning of the experiment, and Ang-(1–7), A779, or saline was administered daily in a single injection for 8 days. Cellular ultrastructural changes were analyzed by transmission electron microscopy. Stx2 induced neurodegeneration, axonal demyelination, alterations in synapse, and oligodendrocyte and astrocyte damage, accompanied by edema. Ang-(1–7) prevented neuronal damage triggered by the toxin in 55.6 ± 9.5% of the neurons and the Stx2-induced synapse dysfunction was reversed. In addition, Ang-(1–7) blocked Stx2-induced demyelination in 92 ± 4% of the axons. Oligodendrocyte damage caused by Stx2 was prevented by Ang-(1–7) but astrocytes were only partially protected by the peptide (38 ± 5% of astrocytes were preserved). Ang-(1–7) treatment resulted in 50% reduction in the number of activated microglial cells induced by Stx2, suggesting an anti-inflammatory action. All these beneficial effects elicited by Ang-(1–7) were blocked by the Mas receptor antagonist and thus it was concluded that Ang-(1–7) protects mainly neurons and oligodendrocytes, and partially astrocytes, in the central nervous system through Mas receptor stimulation. | |
dc.language | eng | |
dc.publisher | American Physiological Society | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1152/ajpregu.00467.2015 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.physiology.org/doi/10.1152/ajpregu.00467.2015 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | ANGIOTENSIN-(1-7) | |
dc.subject | MAS RECEPTOR | |
dc.subject | NEURON | |
dc.subject | OLIGODENDROCYTE | |
dc.subject | ASTROCYTE | |
dc.title | Angiotensin-(1–7) protects from brain damage induced by shiga toxin 2-producing enterohemorrhagic Escherichia coli | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |