A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study

dc.creatorGimeno, Marina
dc.creatorPinczowski, Pedro
dc.creatorPérez, Marta
dc.creatorGiorello, Antonella
dc.creatorMartinez, Miguel Angel
dc.creatorSantamaría, Jesús
dc.creatorArruebo, Manuel
dc.creatorLuján, Lluis
dc.date2015-10
dc.identifierhttp://hdl.handle.net/11336/36650
dc.identifierGimeno, Marina; Pinczowski, Pedro; Pérez, Marta; Giorello, Antonella; Martinez, Miguel Angel; et al.; A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study; Elsevier; European Journal Of Pharmaceutics And Biopharmaceutics; 96; 10-2015; 264-271
dc.identifier0939-6411
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionA new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin.
dc.descriptionFil: Gimeno, Marina. Universidad de Zaragoza; España
dc.descriptionFil: Pinczowski, Pedro. Universidad de Zaragoza; España
dc.descriptionFil: Pérez, Marta. Universidad de Zaragoza; España
dc.descriptionFil: Giorello, Antonella. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica ; Argentina
dc.descriptionFil: Martinez, Miguel Angel. Universidad de Zaragoza; España. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN; España
dc.descriptionFil: Santamaría, Jesús. Universidad de Zaragoza; España. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN; España
dc.descriptionFil: Arruebo, Manuel. Universidad de Zaragoza; España. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN; España
dc.descriptionFil: Luján, Lluis. Universidad de Zaragoza; España
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0939641115003392
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejpb.2015.08.007
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectAntibiotic
dc.subjectControlled Release
dc.subjectHollow Steel Implant
dc.subjectMedical Device
dc.subjectOrthopedic Surgery
dc.subjectStaphylococcus Aureus
dc.subjecthttps://purl.org/becyt/ford/3.1
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleA controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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