Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice

dc.creatorPazos, Patricia
dc.creatorLanari, Claudia Lee Malvina
dc.creatorMolinolo, Alfredo
dc.date2001-02
dc.identifierhttp://hdl.handle.net/11336/30846
dc.identifierMolinolo, Alfredo; Lanari, Claudia Lee Malvina; Pazos, Patricia; Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice; Pergamon-Elsevier Science Ltd.; Leukemia Research; 25; 2; 2-2001; 165-167
dc.identifier0145-2126
dc.identifier1873-5835
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionIn a previous paper we reported the occurrence of a high incidence of lymphomas in N-methyl-N-nitrosourea (MNU)-treated mice, in the course of an experiment of combined chemical-hormonal carcinogenesis in mammary gland, in which we used medroxyprogesterone acetate (MPA) and MNU in different treatment protocols. In this report we have analyzed the action of MPA in the leukemogenic effects of MNU, by specifically selecting for the analysis experimental groups in which only few mammary carcinomas had developed. A high incidence of lymphomas (65%, median latency: 176 days) was registered in MNU-treated mice, and the administration of MPA was associated with a significant reduction in the incidence of lymphomas (P<0.001) in all protocols.
dc.descriptionFil: Pazos, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.descriptionFil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.descriptionFil: Molinolo, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherPergamon-Elsevier Science Ltd.
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.lrjournal.com/article/S0145-2126(00)00116-8/fulltext
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0145-2126(00)00116-8
dc.relationinfo:eu-repo/semantics/altIdentifier/pmid/11166832
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectLymphoma
dc.subjectImmunohistochemistry
dc.subjectMedroxyprogesterone Acetate
dc.subjecthttps://purl.org/becyt/ford/3.1
dc.subjecthttps://purl.org/becyt/ford/3
dc.subjecthttps://purl.org/becyt/ford/3.1
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleProtective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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