Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation

dc.creatorFranzoni, Maria Belen
dc.creatorGraafen, D.
dc.creatorBuljubasich Gentiletti, Lisandro
dc.creatorSchreiber, L. M.
dc.creatorSpiess, H. W.
dc.creatorMünnemann, K.
dc.date2013-09
dc.identifierhttp://hdl.handle.net/11336/26032
dc.identifierFranzoni, Maria Belen; Graafen, D.; Buljubasich Gentiletti, Lisandro; Schreiber, L. M.; Spiess, H. W.; et al.; Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation; Royal Society of Chemistry; Physical Chemistry Chemical Physics; 15; 40; 9-2013; 17233-17239
dc.identifier1463-9076
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionHyperpolarization has found many applications in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). However, its usage is still limited to the observation of relatively fast processes because of its short lifetimes. This issue can be circumvented by storing the hyperpolarization in a slowly relaxing singlet state. Symmetrical molecules hyperpolarized by Parahydrogen Induced Hyperpolarization (PHIP) provide a straightforward access to hyperpolarized singlet states because the initial parahydrogen singlet state is preserved at almost any magnetic field strength. In these systems, which show a remarkably long 1H singlet state lifetime of several minutes, the conversion of the NMR silent singlet state to observable magnetization is feasible due to the existence of singlet-triplet level anti-crossings. Here, we demonstrate that scaling the chemical shift Hamiltonian by rf irradiation is sufficient to transform the singlet into an observable triplet state. Moreover, because the application of one long rf pulse is only partially converting the singlet state, we developed a multiconversion sequence consisting of a train of long rf pulses resulting in successive singlet to triplet conversions. This sequence is used to measure the singlet state relaxation time in a simple way at two different magnetic fields. We show that this approach is valid for almost any magnetic field strength and can be performed even in the less homogeneous field of an MRI scanner, allowing for new applications of hyperpolarized NMR and MRI.
dc.descriptionFil: Franzoni, Maria Belen. Max Planck Institute for Polymer Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.descriptionFil: Graafen, D.. Max Planck Institute for Polymer Research; Alemania. Johannes Gutenberg University Medical Center; Alemania
dc.descriptionFil: Buljubasich Gentiletti, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
dc.descriptionFil: Schreiber, L. M.. Johannes Gutenberg University Medical Center; Alemania
dc.descriptionFil: Spiess, H. W.. Max Planck Institute for Polymer Research; Alemania
dc.descriptionFil: Münnemann, K.. Max Planck Institute for Polymer Research; Alemania
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherRoyal Society of Chemistry
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C3CP52029C
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/-/content/articlelanding/2013/cp/c3cp52029c/unauth#!divAbstract
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectLong Lived States
dc.subjectHyperpolarization
dc.subjectParahydrogen
dc.subjectPhip
dc.subjecthttps://purl.org/becyt/ford/1.3
dc.subjecthttps://purl.org/becyt/ford/1
dc.titleHyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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