Diabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats

dc.creatorWhite, Verónica
dc.creatorJawerbaum, Alicia Sandra
dc.creatorMazzucco, María Belén
dc.creatorGauster, Martin
dc.creatorDesoye, Gernot
dc.creatorHiden, Ursula
dc.date2015-01
dc.identifierhttp://hdl.handle.net/11336/13857
dc.identifierWhite, Verónica; Jawerbaum, Alicia Sandra; Mazzucco, María Belén; Gauster, Martin; Desoye, Gernot; et al.; Diabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats; Nature Publishing Group; Pediatric Research; 77; 1-1; 1-2015; 48-55
dc.identifier0031-3998
dc.identifier1530-0447
dc.descriptionBackground: Diabetes in pregnancy affects fetal growth and development. The insulin/insulin-like growth factors (IGF) system comprising insulin, IGF, their receptors, and binding proteins, has been implicated in fetal growth regulation. This study tested the hypothesis that maternal diabetes alters the fetal insulin/IGF system in a tissue-specific manner. Methods: Wistar rats were rendered diabetic by neonatal administration of streptozotocin and mated with control rats. At day 21 of gestation, the weights of fetuses, placentas, and fetal organs (heart, lung, liver, stomach, intestine, and pancreas) were determined. Maternal and fetal plasma concentrations of insulin, IGF1, and IGF2 were measured by ELISA, and expression of IGF1, IGF2, IGF1R, IGF2R, IR, IGFBP1, BP2, and BP3 in placenta and fetal organs by qPCR. Results: The well-known increase in fetal growth in this model of mild diabetes is accompanied by elevated insulin and IGF1 levels and alterations of the insulin/IGF system in the fetus and the placenta. These alterations were organ and gene specific. The insulin/IGF system was generally upregulated, especially in the fetal heart, while it was downregulated in fetal lung. Conclusion: In our model of mild diabetes, the effect of maternal diabetes on fetal weight and fetal insulin/IGF system expression is organ specific with highly sensitive organs such as lung and heart, and organs that were less affected, such as stomach.
dc.descriptionFil: White, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.descriptionFil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.descriptionFil: Mazzucco, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.descriptionFil: Gauster, Martin. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; Austria
dc.descriptionFil: Desoye, Gernot. Medical University of Graz. Department of Obstetrics and Gynaecology; Austria
dc.descriptionFil: Hiden, Ursula. Medical University of Graz. Department of Obstetrics and Gynaecology; Austria
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dc.languageeng
dc.publisherNature Publishing Group
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/pr/journal/v77/n1-1/full/pr2014139a.html#affil-auth
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1038/pr.2014.139
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectMaternal Diabetes
dc.subjectFetus
dc.subjectPlacenta
dc.subjectInsulin-Igf
dc.subjectPregnancy
dc.subjecthttps://purl.org/becyt/ford/1.6
dc.subjecthttps://purl.org/becyt/ford/1
dc.titleDiabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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