dc.creatorSilva Alvarez, Maria Valeria
dc.creatorFranchini, Gisela Raquel
dc.creatorPórfido, Jorge Luis
dc.creatorKennedy, Malcolm W.
dc.creatorFerreira, Ana M.
dc.creatorCórsico, Betina
dc.date.accessioned2018-03-09T17:41:44Z
dc.date.accessioned2018-11-06T11:12:37Z
dc.date.available2018-03-09T17:41:44Z
dc.date.available2018-11-06T11:12:37Z
dc.date.created2018-03-09T17:41:44Z
dc.date.issued2015-03
dc.identifierSilva Alvarez, Maria Valeria; Franchini, Gisela Raquel; Pórfido, Jorge Luis; Kennedy, Malcolm W.; Ferreira, Ana M.; et al.; Lipid-Free Antigen B Subunits from Echinococcus granulosus: Oligomerization, Ligand Binding, and Membrane Interaction Properties; Public Library of Science; Neglected Tropical Diseases; 9; 3; 3-2015; 1-23; e0003552
dc.identifier1935-2735
dc.identifierhttp://hdl.handle.net/11336/38407
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1847192
dc.description.abstractThe hydatid disease parasite Echinococcus granulosus has a restricted lipid metabolism, and needs to harvest essential lipids from the host. Antigen B (EgAgB), an abundant lipoprotein of the larval stage (hydatid cyst), is thought to be important in lipid storage and transport. It contains a wide variety of lipid classes, from highly hydrophobic compounds to phospholipids. Its protein component belongs to the cestode-specific Hydrophobic Ligand Binding Protein family, which includes five 8-kDa isoforms encoded by a multigene family (EgAgB1-EgAgB5). How lipid and protein components are assembled into EgAgB particles remains unknown. EgAgB apolipoproteins self-associate into large oligomers, but the functional contribution of lipids to oligomerization is uncertain. Furthermore, binding of fatty acids to some EgAgB subunits has been reported, but their ability to bind other lipids and transfer them to acceptor membranes has not been studied.
dc.languageeng
dc.publisherPublic Library of Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1371/journal.pntd.0003552
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003552
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLipid binding proteins
dc.subjectAntigen B
dc.subjectHydatid disease
dc.subjectE. granulosus
dc.titleLipid-Free Antigen B Subunits from Echinococcus granulosus: Oligomerization, Ligand Binding, and Membrane Interaction Properties
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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