Interleukin-1b-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and a-melanocyte-stimulating hormone prevented these effects

dc.creatorMachado, Ivana Noelia
dc.creatorGonzalez, Patricia Verónica
dc.creatorVilcaes, Aldo Alejandro
dc.creatorCarniglia, Lila
dc.creatorSchiöth, Helgi B.
dc.creatorLasaga, Mercedes Isabel
dc.creatorScimonelli, Teresa Nieves
dc.date2015-01
dc.identifierhttp://hdl.handle.net/11336/15215
dc.identifierMachado, Ivana Noelia; Gonzalez, Patricia Verónica; Vilcaes, Aldo Alejandro; Carniglia, Lila; Schiöth, Helgi B.; et al.; Interleukin-1b-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and a-melanocyte-stimulating hormone prevented these effects; Elsevier Inc; Brain Behavior And Immunity; 46; 1-2015; 137-146
dc.identifier0889-1591
dc.descriptionThe immune system is an important modulator of learning, memory and neural plasticity. Interleukin 1β (IL-1β), a pro-inflammatory cytokine, significantly affects several cognitive processes. Previous studies by our group have demonstrated that intrahippocampal administration of IL-1β impairs reconsolidation of contextual fear memory. This effect was reversed by the melanocortin alpha-melanocyte-stimulating hormone (α-MSH). The mechanisms underlying the effect of IL-1β on memory reconsolidation have not yet been established. Therefore, we examined the effect of IL-1β on glutamate release, ERK phosphorylation and the activation of the transcription factor zinc finger- 268 (zif268) during reconsolidation. Our results demonstrated that IL-1β induced a significant decrease of glutamate release after reactivation of the fear memory and this effect was related to calcium concentration in hippocampal synaptosomes. IL-1β also reduced ERK phosphorylation and zif268 expression in the hippocampus. Central administration of α-MSH prevented the decrease in glutamate release, ERK phosphorylation and zif268 expression induced by IL-1β. Our results establish possible mechanisms involved in the detrimental effect of IL-1β on memory reconsolidation and also indicate that α-MSH may exert a beneficial modulatory role in preventing IL-1β effects.
dc.descriptionFil: Machado, Ivana Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
dc.descriptionFil: Gonzalez, Patricia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
dc.descriptionFil: Vilcaes, Aldo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina
dc.descriptionFil: Carniglia, Lila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.descriptionFil: Schiöth, Helgi B.. Uppsala University; Suecia
dc.descriptionFil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.descriptionFil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
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dc.languageeng
dc.publisherElsevier Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbi.2015.01.012
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S088915911500015X
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subjectInterleukin 1 Beta
dc.subjectAlpha-Melanocyte-Stimulating Hormone
dc.subjectMemory Reconsolidation
dc.subjectGlutamate Release
dc.subjectZif268
dc.subjectErk
dc.subjectCa2+
dc.subjectHippocampus
dc.subjecthttps://purl.org/becyt/ford/3.1
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleInterleukin-1b-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and a-melanocyte-stimulating hormone prevented these effects
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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