dc.creator | Troncoso, María Fernanda | |
dc.creator | Ferragut, Fátima | |
dc.creator | Bacigalupo, Maria Lorena | |
dc.creator | Cardenas Delgado, Victor Manuel | |
dc.creator | Nugnes, Lorena Gisela | |
dc.creator | Gentilini, Lucas Daniel | |
dc.creator | Laderach, Diego Jose | |
dc.creator | Wolfenstein, Carlota Elisa | |
dc.creator | Compagno, Daniel Georges | |
dc.creator | Rabinovich, Gabriel Adrian | |
dc.creator | Elola, Maria Teresa | |
dc.date.accessioned | 2017-06-13T19:29:37Z | |
dc.date.available | 2017-06-13T19:29:37Z | |
dc.date.created | 2017-06-13T19:29:37Z | |
dc.date.issued | 2014-10 | |
dc.identifier | Troncoso, María Fernanda; Ferragut, Fátima; Bacigalupo, Maria Lorena; Cardenas Delgado, Victor Manuel; Nugnes, Lorena Gisela; et al.; Galectin-8: a matricellular lectin with key roles in angiogenesis; Oxford University Press; Glycobiology; 24; 10; 10-2014; 907-914 | |
dc.identifier | 0959-6658 | |
dc.identifier | http://hdl.handle.net/11336/18126 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.description.abstract | Galectin-8 (gal-8) is a “tandem-repeat”-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis. | |
dc.language | eng | |
dc.publisher | Oxford University Press | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/glycob/cwu054 | |
dc.relation | info:eu-repo/semantics/altIdentifier/ark/https://academic.oup.com/glycob/article-lookup/doi/10.1093/glycob/cwu054 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Galectin-8 | |
dc.subject | Angiogenesis | |
dc.subject | Endothelium | |
dc.subject | Cd166 | |
dc.title | Galectin-8: a matricellular lectin with key roles in angiogenesis | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |