Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection

dc.creatorEriko, Chiba
dc.creatorTomosada, Yohsuke
dc.creatorVizoso Pinto, María Guadalupe
dc.creatorSalva, Maria Susana
dc.creatorTakahashi, Takuya
dc.creatorTsukida, Kohichiro
dc.creatorKitazawa, Haruki
dc.creatorAlvarez, Gladis Susana
dc.creatorVillena, Julio Cesar
dc.date2013-10
dc.identifierhttp://hdl.handle.net/11336/2366
dc.identifierEriko, Chiba; Tomosada, Yohsuke; Vizoso Pinto, María Guadalupe; Salva, Maria Susana; Takahashi, Takuya; et al.; Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection; Elsevier Science; International Immunopharmacology; 17; 2; 10-2013; 373-382
dc.identifier1567-5769
dc.descriptionPreviously we showed that orally administered Lactobacillus rhamnosus CRL1505 beneficially regulated the balance between pro- and anti-inflammatory mediators in the lungs of poly(I:C)-challenged mice, allowing an effective inflammatory response against the TLR3/RIG-I agonist but at the same time reducing tissue damage. The aim of the present study was to investigate whether oral administration of the CRL1505 strain was able to improve resistance against respiratory syncytial virus (RSV) infection in infant mice and to evaluate the immunological mechanisms involved in the immunobiotic effect. We demonstrated that treatment of 3-week old BALB/c mice with L. rhamnosus CRL1505 significantly reduce lung viral loads and tissue injuries after the challenge with RSV. Moreover, we showed that the protective effect achieved by the CRL1505 strain is related to its capacity to differentially modulate respiratory antiviral immune response. Our results shows that IFN-γ and IL-10 secreted in response to L. rhamnosus CRL1505 oral stimulation would modulate the pulmonary innate immune microenvironment conducting to the activation of CD103+ and CD11bhigh dendritic cells and the generation of CD3+CD4+IFN-γ+ Th1 cells with the consequent attenuation of the strong and damaging Th2 reactions associated with RSV challenge. Our results indicate that modulation of the common mucosal immune system by immunobiotics could favor protective immunity against respiratory viral pathogens with a high attack rate in early infancy, such as RSV.
dc.descriptionFil: Eriko, Chiba. Tohoku University; Japón
dc.descriptionFil: Tomosada, Yohsuke. Tohoku University; Japón
dc.descriptionFil: Vizoso Pinto, María Guadalupe. Universidad Nacional de Tucuman. Facultad de Medicina. Departamento Biomedico. Laboratorio de Fisiologia y Farmacologia Vascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.descriptionFil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
dc.descriptionFil: Takahashi, Takuya. Tohoku University; Japón
dc.descriptionFil: Tsukida, Kohichiro. Tohoku University; Japón
dc.descriptionFil: Kitazawa, Haruki. Tohoku University; Japón
dc.descriptionFil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clínica Aplicada; Argentina
dc.descriptionFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://sciencedirect.com/science/journal/15675769
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1567576913002658
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.intimp.2013.06.024
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectANTIVIRAL IMMUNITY
dc.subjectCRL1505
dc.subjectL. RHAMNOSUS
dc.subjectRESPIRATORY SYNCYTIAL VIRUS
dc.subjectRESPIRATORY TRACT
dc.subjecthttps://purl.org/becyt/ford/3.1
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleImmunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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