Artículos de revistas
EX-MET study: exercise in prevention on of metabolic syndrome – a randomized multicenter trial: rational and design
Fecha
2018Registro en:
BMC Public Health. 2018 Apr 02;18(1):437
10.1186/s12889-018-5343-7
Autor
Tjønna, Arnt Erik
Ramos, Joyce S.
Pressler, Axel
Halle, Martin
Jungbluth, Klaus
Ermacora, Erika
Salvesen, Øyvind
Rodrigues, Jhennyfer
Bueno Júnior, Carlos Roberto
Munk, Peter Scott
Coombes, Jeff
Wisløff, Ulrik
Institución
Resumen
Abstract
Background
Metabolic syndrome substantially increases risk of cardiovascular events. It is therefore imperative to develop or optimize ways to prevent or attenuate this condition. Exercise training has been long recognized as a corner-stone therapy for reducing individual cardiovascular risk factors constituting the metabolic syndrome. However, the optimal exercise dose and its feasibility in a real world setting has yet to be established.
The primary objective of this randomized trial is to investigate the effects of different volumes of aerobic interval training (AIT) compared to the current exercise guideline of moderate-intensity continuous training (MICT) on the composite number of cardiovascular disease risk factors constituting the metabolic syndrome after a 16 week, 1-year, and 3-year follow-up.
Methods
This is a randomized international multi-center trial including men and women aged ≥30 years diagnosed with the metabolic syndrome according to the International Diabetes Federation criteria. Recruitment began in August 2012 and concluded in December 2016. This trial consists of supervised and unsupervised phases to evaluate the efficacy and feasibility of different exercise doses on the metabolic syndrome in a real world setting. This study aims to include and randomize 465 participants to 3 years of one of the following training groups: i) 3 times/week of 4 × 4 min AIT at 85–95% peak heart rate (HRpeak); ii) 3 times/week of 1 × 4 min AIT at 85–95% HRpeak; or iii) 5–7 times/week of ≥30 min MICT at 60–70% HRpeak. Clinical examinations, physical tests and questionnaires are administered to all participants during all testing time points (baseline, 16 weeks and after 1-, and 3-years).
Discussion
This multi-center international trial indeed aims to ease the burden in healthcare/economic cost arising from treating end-stage CVD related conditions such as stroke and myocardial infarction, that could eventually emerge from the metabolic syndrome condition.
Trial registration
Clinical registration number:
NCT01676870
, ClinicalTrials.gov (August 31, 2012).