dc.creator | Salomão, Roberta Garcia | |
dc.creator | Carvalho, Luciana Martins de | |
dc.creator | Izumi, Clarice | |
dc.creator | Czernisz, Érika Silva | |
dc.creator | Rosa, Jose Cesar | |
dc.creator | Antonini, Sonir Roberto Rauber | |
dc.creator | Bueno, Ana Carolina | |
dc.creator | Almada, Maria Olimpia Ribeiro do Vale | |
dc.creator | Coelho-Landell, Carolina de Almeida | |
dc.creator | Jordão, Alceu Afonso | |
dc.creator | Ferriani, Virginia Paes Leme | |
dc.creator | Monteiro, Jacqueline Pontes | |
dc.date.accessioned | 2018-01-14T04:17:55Z | |
dc.date.accessioned | 2018-07-04T17:14:19Z | |
dc.date.available | 2018-01-14T04:17:55Z | |
dc.date.available | 2018-07-04T17:14:19Z | |
dc.date.created | 2018-01-14T04:17:55Z | |
dc.date.issued | 2018 | |
dc.identifier | Pediatric Rheumatology. 2018 Jan 09;16(1):4 | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/51495 | |
dc.identifier | 10.1186/s12969-017-0220-y | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1646532 | |
dc.description.abstract | Abstract
Background
Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein.
Methods
We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-α, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers. Physiological and anthropometric variables of c-SLE and healthy controls were compared by ANCOVA. k-cluster was used to separate c-SLE into two different groups with the best and the worst metabolic profile according to previous analysis showing some metabolites that were statistically different from controls, such as homocysteine, TNF-α, hs-CRP and folate levels. These two clusters were again compared with the control group regarding nutritional parameters, lipid profile and also proteomic data.
Results
Individuals with c-SLE presented higher BMI, WC, homocysteine, triglycerides, TNF-α, hs-CRP and lower folate levels when compared to controls. We found 10 proteins whose relative abundances were statistically different between control group and lupus clusters with the best (LCBMP) and the worst metabolic profile (LCWMP). A significant positive correlation was found between TNF-α and triglycerides and between hs-CRP and duration of corticosteroid therapy.
Conclusion
Cardiovascular disease (CVD) risk parameters were worse in c-SLE. A less protective CVD proteomic profile was found in LCWMP. | |
dc.language | eng | |
dc.publisher | BioMed Central | |
dc.relation | Pediatric Rheumatology | |
dc.rights | The Author(s). | |
dc.rights | openAccess | |
dc.subject | Proteomic | |
dc.subject | Nutritional status | |
dc.subject | Homocysteine | |
dc.subject | Folic acid | |
dc.subject | Tumor necrosis factor alpha | |
dc.subject | Childhood onset systemic lupus Erythematosus | |
dc.title | Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus? | |
dc.type | Artículos de revistas | |