Artículos de revistas
High-fat diet or low-protein diet changes peritoneal macrophages function in mice
Fecha
2016Registro en:
Nutrire. 2016 Jun 28;41(1):6
10.1186/s41110-016-0006-x
Autor
Santos, Ed Wilson
Oliveira, Dalila Cunha de
Hastreiter, Araceli
Beltran, Jackeline Soares de Oliveira
Rogero, Marcelo Macedo
Fock, Ricardo Ambrósio
Borelli, Primavera
Institución
Resumen
Abstract
Background
Obesity and protein malnutrition are major food problems nowadays, affecting billions of people around the world. The nutrition transition that has occurred in recent decades is changing the nutritional profile, reducing malnutrition and increasing the percentage of obese people. The innate immune response is greatly influenced by diet, with significant changes in both malnutrition and obesity. Therefore, we investigate the effects of protein malnutrition and obesity in nutritional and immunological parameters in mice.
Results
Peritoneal macrophages of malnourished animals showed reduced functions of adhesion, spreading, and fungicidal activity; production of hydrogen peroxide and nitric oxide were lower, reflecting changes in the innate immune response. However, the high-fat animals had macrophage functions slightly increased.
Conclusions
Animals subjected to low-protein diet have immunosuppression, and animals subjected to high-fat diet increased visceral adipose tissue and the presence of an inflammatory process with increased peritoneal macrophage activity and similar systemic changes to metabolic syndrome.