Artículos de revistas
Effects of 3,5,3′-triiodothyroacetic acid, nanoencapsulated or not, on intact and atrophic skin in rats
Fecha
2014-08Registro en:
Journal of Nanotechnology in Engineering and Medicine, New York : American Society of Mechanical Engineers - ASME, v. 5, n. 3, p. 031001-1-031001-8, Aug. 2014
1949-2944
10.1115/1.4028695
Autor
Pera, Daniele Trevizan
Planello, Jéssica Freitas
Cancino, Juliana
Polikarpov, Igor
Zucolotto, Valtencir
Avó, Lucimar Retto da Silva de
Germano, Carla Maria Ramos
Melo, Débora Gusmão
Institución
Resumen
We aimed to investigate 3,5,3′-triiodothyroacetic acid (TRIAC) effects on intact and atrophic skin induced by glucocorticoids (GCs) in rats and the effects induced by nanoencapsulation. The effects of TRIAC and nanoencapsulated TRIAC were evaluated on intact and atrophic skin in TRIAC experiment and nanoencapsulated TRIAC experiment, respectively. Both experiments had two phases: phase I, cutaneous atrophy was induced; phase II, TRIAC or nanoencapsulated TRIAC was administrated. Our results showed that topical use of TRIAC with or without nanoencapsulation was able to reverse cutaneous atrophy. Nanoencapsulated TRIAC showed less systemic changes than TRIAC; therefore, it is possibly a safer drug for topical administration.