Leishmaniasis and Chagas disease chemotherapy: a critical review

dc.creatorJardim, Izaltina Silva
dc.creatorThiemann, Otavio Henrique
dc.creatorAnibal, Fernanda F.
dc.date.accessioned2016-06-01T13:00:20Z
dc.date.accessioned2018-07-04T17:08:38Z
dc.date.available2016-06-01T13:00:20Z
dc.date.available2018-07-04T17:08:38Z
dc.date.created2016-06-01T13:00:20Z
dc.date.issued2014-10
dc.identifierJournal of the Brazilian Chemical Society,São Paulo : Sociedade Brasileira de Química - SBQ,v. 25, n. 10, p. 1810-1823, Oct. 2014
dc.identifier0103-5053
dc.identifierhttp://www.producao.usp.br/handle/BDPI/50255
dc.identifier10.5935/0103-5053.20140229
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1645237
dc.description.abstractLeishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp and Trypanosoma cruzi, respectively, are among the most important parasitic diseases, affecting millions of people and considered to be within the most relevant group of neglected tropical diseases. Chemotherapy is the main alternative to control such parasites, nevertheless, current treatments are far from satisfactory. This review outlines the current understanding on different drugs against leishmaniasis and Chagas disease and their mechanism of action. Recent approaches in the area of anti-leishmanial and trypanocidal therapies are also enumerated, as well as the search for new drugs.
dc.languageeng
dc.publisherSociedade Brasileira de Química - SBQ
dc.publisherSão Paulo
dc.relationJournal of the Brazilian Chemical Society
dc.rightsCopyright Sociedade Brasileira de Química
dc.rightsrestrictedAccess
dc.subjectVisceral leishmaniasis
dc.subjectAmerican tegumentary leishmaniasis
dc.subjectChagas disease
dc.subjectLeishmania
dc.subjectTrypanosoma cruzi
dc.subjectChemotherapy
dc.titleLeishmaniasis and Chagas disease chemotherapy: a critical review
dc.typeArtículos de revistas


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