Snake venom L-amino acid oxidases: an overview on their antitumor effects

dc.creatorCosta, Tássia R
dc.creatorBurin, Sandra M
dc.creatorMenaldo, Danilo L
dc.creatorCastro, Fabíola A
dc.creatorSampaio, Suely V
dc.date.accessioned2015-02-09T14:19:54Z
dc.date.accessioned2018-07-04T17:01:21Z
dc.date.available2015-02-09T14:19:54Z
dc.date.available2018-07-04T17:01:21Z
dc.date.created2015-02-09T14:19:54Z
dc.date.issued2014-06-02
dc.identifierJournal of Venomous Animals and Toxins including Tropical Diseases. 2014 Jun 02;20(1):23
dc.identifierhttp://dx.doi.org/10.1186/1678-9199-20-23
dc.identifierhttp://www.producao.usp.br/handle/BDPI/47911
dc.identifier10.1186/1678-9199-20-23
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1643590
dc.description.abstractThe L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and have been widely studied due to their widespread presence and various effects, such as apoptosis induction, cytotoxicity, induction and/or inhibition of platelet aggregation, hemorrhage, hemolysis, edema, as well as antimicrobial, antiparasitic and anti-HIV activities. The isolated and characterized snake venom LAAOs have become important research targets due to their potential biotechnological applications in pursuit for new drugs of interest in the scientific and medical fields. The current study discusses the antitumor effects of snake venom LAAOs described in the literature to date, highlighting the mechanisms of apoptosis induction proposed for this class of proteins.
dc.languageen
dc.publisherBMC
dc.relationJournal of Venomous Animals and Toxins including Tropical Diseases
dc.rightsCosta et al.; licensee BioMed Central Ltd.
dc.rightsopenAccess
dc.subjectSnake venoms
dc.subjectL-amino acid oxidases
dc.subjectAntitumor effects
dc.subjectApoptosis
dc.titleSnake venom L-amino acid oxidases: an overview on their antitumor effects
dc.typeArtículos de revistas


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