Artículos de revistas
Metronidazole release using natural rubber latex as matrix
Fecha
2010-01Registro en:
Materials Research,São Carlos : Universidade Federal de São Carlos - UFSCar, v. 13, n. 1, p. 57-61, Jan./Mar. 2010
1516-1439
10.1590/S1516-14392010000100013
Autor
Herculano, Rondinelli Donizetti
Guimarães, Sergio Augusto Catanzaro
Belmonte, Gustavo Campos
Duarte, Marco Antonio Hungaro
Oliveira Junior, Osvaldo Novais de
Kinoshita, Angela
Graeff, Carlos Frederico de Oliveira
Institución
Resumen
Natural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent
matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation
of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system
comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed.
MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and
anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of
infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we
have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the
inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in
solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different
temperatures, from –100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis
showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization
temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the
membrane polymerized at –100 °C, which does release 77,1% of its MET content for up 310 hours.