Molecular properties of fatty acids related to PPAR binding and metabolic diseases

dc.creatorMaltarollo, Vinicius Gonçalves
dc.creatorHonorio, Káthia Maria
dc.date.accessioned2014-09-04T14:10:08Z
dc.date.accessioned2018-07-04T16:50:26Z
dc.date.available2014-09-04T14:10:08Z
dc.date.available2018-07-04T16:50:26Z
dc.date.created2014-09-04T14:10:08Z
dc.date.issued2013-07
dc.identifierMedicinal Chemistry Research, Basel, v. 22, n. 7, p. 3126–3133, jul. 2013
dc.identifier1054-2523
dc.identifierhttp://www.producao.usp.br/handle/BDPI/46086
dc.identifierhttp://dx.doi.org/10.1007/s00044-012-0285-6
dc.identifierhttp://link.springer.com/article/10.1007%2Fs00044-012-0285-6
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1641080
dc.description.abstractPeroxisome proliferator-activated receptor (PPAR) is a class of nuclear receptors responsible for the transcription of genes that regulate the metabolism of carbohydrates and lipids. The main endogenous ligands of PPARs are fatty acids, leukotrienes and derivatives. The PPAR family has three isoforms: α, γ, and δ. To understand the main interactions responsible for the PPAR selectivity of a subset of ligands, we performed molecular modeling studies on a set of 16 fatty acids. From the results obtained, we found that stereochemical, hydrophobic, and polar properties are correlated with PPAR selectivity and can be used to design new ligands with improved biological selectivity.
dc.languageeng
dc.publisherSpringer
dc.publisherBasel
dc.relationMedicinal Chemistry Research
dc.rightsCopyright Springer Science+Business Media
dc.rightsrestrictedAccess
dc.subjectPPAR
dc.subjectFatty acids
dc.subjectMolecular modeling
dc.subjectDrug design
dc.titleMolecular properties of fatty acids related to PPAR binding and metabolic diseases
dc.typeArtículos de revistas


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