dc.creator | Bicev, Renata Naporano | |
dc.creator | Oliveira, Cristiano Luis Pinto de | |
dc.creator | Demasi, M. | |
dc.date.accessioned | 2014-04-01T14:09:33Z | |
dc.date.accessioned | 2018-07-04T16:45:08Z | |
dc.date.available | 2014-04-01T14:09:33Z | |
dc.date.available | 2018-07-04T16:45:08Z | |
dc.date.created | 2014-04-01T14:09:33Z | |
dc.date.issued | 2013-02-26 | |
dc.identifier | Reunião Anual de Usuários do LNLS RAU, XXIII, 2013, Campinas | |
dc.identifier | http://www.producao.usp.br/handle/BDPI/44349 | |
dc.identifier | http://lnls.cnpem.br/rau/files/2013/04/Livro-Resumos-23RAU.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1639876 | |
dc.description.abstract | The process of intracellular proteolysis (protein degradation) is a regulatory mechanism of cellular homeostasis with the same level of importance as gene expression.The proteasome is a proteolytic complex responsible for protein degradation
and consists of a catalytic core unit called the 20S(20SPT) where the hydrolysis
occurs, engaged in one or both ends by regulatory units, called 19S, responsible
for the recognition of poly-ubiquitylated proteins, unfolding and translocation of
them to the 20S catalytic chamber. However, the catalytic unit (20SPT) can also
degrade not marked proteins with poly-ubiquitin tail, as in the case of oxidized
proteins. Oxidized proteins have a tendency to form aggregates (a phenomenon
that underlies human neurodegenerative diseases), and therefore they must be effectively removed from the living cell. Interestingly, the cells have approximately
1/3 of proteasome without regulatory units, i.e. only the 20S catalytic unit. | |
dc.language | eng | |
dc.publisher | Comitê dos Usuários do LNLS | |
dc.publisher | CNPEM/LNLS | |
dc.publisher | Campinas | |
dc.relation | Reunião Anual de Usuários do LNLS RAU, XXIII | |
dc.rights | Renata Naporano Bicev | |
dc.rights | openAccess | |
dc.subject | 20S proteasome | |
dc.subject | Structural study | |
dc.subject | SAXS | |
dc.title | 20S Proteasome: Structural study using SAXS. | |
dc.type | Actas de congresos | |